4,9-Epoxycevan-3β,4α,12,14,16β,17,20-heptol-3-veratrumat Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Beschreibung
This steroidal alkaloid from Veratrum viride was given this name by Bosetti. It is
almost certainly identical with the amorphous veratrine isolated by Schmidt and
Koppen, Merck, and Wright and Luff. The base is a colourless, amorphous powder
which melts over a wide range. It has [α]
22D + 8.0° (EtOH) and yields a sulphate nonahydrate which forms colourless silky needles that resinify in air. The nitrate
is only sparingly soluble in H2O. The solution of the alkaloid in H2SO4 becomes
orange-red and eventually crimson with a blue fluorescence while that in HCI is
colourless. Alkaline hydrolysis furnishes veratric acid and cevine.
Verwenden
Veratridine causes Na+ channels to stay open during a sustained membrane depolarization by abolishing inactivation.This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability.
Allgemeine Beschreibung
Veratridine is one of several alkaloids isolated from the seeds of
Schoenocaulon officinale and from the rhizome of
Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family
Liliaceae and genus,
Schoenocaulon. Veratridine is soluble in lipid.
l?uterung methode
It is an alkaloid neurotoxin which prevents inactivation of Na+ channels. Its solubility in EtOH is ~5%; and it separates as a pale yellow powder from an ethanolic solution on addition of Et2O. It forms nitrate, sulfate and perchlorate salts. [McKinney et al. Anal Biochem 153 33 1986, Beilstein 21 V/13 709.]
Einzelnachweise
Merck., Annalen, 95, 200 (1855)
Schmidt, Koppen., Ber., 9, 1115 (1876)
Wright, Luff.,J. Chem. Soc., 35, 421 (1879)
Bosetti., Arch. Pharm., 221,82 (1883)
Blount., Chem. Zeit., 26,334 (1902)
4,9-Epoxycevan-3β,4α,12,14,16β,17,20-heptol-3-veratrumat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
