Raltitrexed
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- CAS-Nr.
- 112887-68-0
- Englisch Name:
- Raltitrexed
- Synonyma:
- Tomudex;Raltirexed;TDX;D1694;CS-664;ZD-1694;Retitrose;ZEN-D-1694;ICI-D-1694;Raltitrexe
- CBNumber:
- CB1222070
- Summenformel:
- C21H22N4O6S
- Molgewicht:
- 458.49
- MOL-Datei:
- 112887-68-0.mol
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Raltitrexed Eigenschaften
- Schmelzpunkt:
- 176-1800C
- Dichte
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: ≥10mg/mL
- pka
- 3.50±0.10(Predicted)
- Aggregatzustand
- solid
- Farbe
- off-white to light yellow
- Wasserl?slichkeit
- H2O: ≥10mg/mL
DMSO: ≥40mg/mL
- InChIKey
- IVTVGDXNLFLDRM-HNNXBMFYSA-N
- SMILES
- C(O)(=O)[C@H](CCC(O)=O)NC(C1SC(N(CC2C=CC3=C(C=2)C(=O)NC(C)=N3)C)=CC=1)=O |&1:3,r|
- CAS Datenbank
- 112887-68-0(CAS DataBase Reference)
Raltitrexed Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/38:Reizt die Augen und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Tomudex was launched in Ireland, France, Luxembourg and the UK for
advanced colorectal cancer and it was prepared in a convergent manner (6 steps)
from diethyl L-glutamate and 6-bromomethyi-2-methyl-quinazolin4(3H)-one.
Tomudex is a highly selective inhibitor of thymidylate synthase (TS), the key enzyme
in the biochemical conversion of dUMP to dTMP. It enters the cell via the reduced
folatefmethotrexate cell membrane carrier and is converted to the polyglutamate
species by folylpolyglutamate synthase within 4h where it then binds to the folate
substrate site of TS. Clinically, it had a 29% response rate in patients with advanced
colorectal cancer. It is water soluble, can be administered as a single dose every
three weeks and had no hepto- or nephrotoxicity.
Chemische Eigenschaften
Yellow Crystalline Powder
Verwenden
Folate-based inhibitor of thymidylate synthase; rapidly and extensively metabolized to its more potent polyglutamate derivatives. Antineoplastic
Raltitrexed Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Raltitrexed Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 396)Lieferanten
112887-68-0()Verwandte Suche:
- RALTITREXED
- (s)-2-[(1-{5-[methyl-(2-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-thiophen-2-yl}-methanoyl)-amino]-pentanedioic acid
- ICI-D-1694
- N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid
- ZD-1694
- L-Glutamic acid, N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-
- (S)-2-(5-(METHYL((2-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)METHYL)AMINO)THIOPHENE-2-CARBOXAMIDO)PENTANEDIOIC ACID
- 4-nitro-2-thiohenic acid
- (2S)-2-[5-[N-Methyl-N-[[(3,4-dihydro-2-methyl-4-oxoquinazolin)-6-yl]methyl]amino]-2-thienylcarbonylamino]glutaric acid
- (S)-2-[5-[N-Methyl-N-[[(3,4-dihydro-2-methyl-4-oxoquinazolin)-6-yl]methyl]amino]-2-thienylcarbonylamino]glutaric acid
- ZEN-D-1694
- Raltitrexed(ToMudex)
- (S)-2-(5-(Methyl((2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)-methyl)amino)thiophene-2-carboxam
- N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]- L-glutamic acid
- L-Glutamic acid, N-((5-(((1,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)- monohydrate
- Raltitrexed monohydrate
- Raltitrexed, >=99%
- CS-664
- (2s)-2-[[5-[methyl-[(2-methyl-4-oxo-1h-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic Acid
- D1694
- Raltitrexed (ZD1694
- Raltitrexed USP/EP/BP
- (S)-2-(5-(Methyl((2-methyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)amino)thiophene-2-carboxamido)pentanedioic acid
- Tomudex
- Raltitrexe
- Retitrose
- TDX
- Raltitrexed, 10 mM in DMSO
- (5-(Methyl((2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)amino)thiophene-2-carbonyl)-L-glutamic acid
- Raltirexed
- 112887-68-0
- 12887-68-0
- 112887-68-7
- C21H22N4O6S
- C21H22N4O6SxH2O
- Active Pharmaceutical Ingredients
- Raltitrexed
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Inhibitors
- 112887-68-0
