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BNP-32 (HUMAN)

BNP-32 (HUMAN) Struktur
124584-08-3
CAS-Nr.
124584-08-3
Englisch Name:
BNP-32 (HUMAN)
Synonyma:
Nesiritide;BNP HUMAN;BNP-32 (HUMAN);Nesiritide TFA;BNP (1-32), HUMAN;Nesiritide (BNP-32);Brain natriuretic pe;Nesiritide [USAN:INN];BNP-32 (HUMAN) USP/EP/BP;BNP-32 (human) hydrochloride
CBNumber:
CB1676347
Summenformel:
C143H244N50O42S4
Molgewicht:
3464.05
MOL-Datei:
124584-08-3.mol

BNP-32 (HUMAN) Eigenschaften

Dichte
1.52±0.1 g/cm3(Predicted)
RTECS-Nr.
EE1534000
storage temp. 
−20°C
Aggregatzustand
powder
Farbe
White to off-white
Wasserl?slichkeit
Soluble in water at 1mg/ml
Sequenz
H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH(Disulfide bridge: Cys10-Cys26)
InChIKey
HPNRHPKXQZSDFX-OAQDCNSJSA-N
CAS Datenbank
124584-08-3

Sicherheit

WGK Germany  3
Speicherklasse 11 - Combustible Solids

BNP-32 (HUMAN) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Nesiritide was introduced in the US as a new intravenous treatment for patients with acutely decompensated congestive heart failure who have dyspnea at rest or with minimal activity. Nesiritide is the first human recombinant form of the potent vasodilatory B-type natriuretic peptide (also known as brain natriuretic peptide), a naturally occurring 32 amino acid peptide with a disulfide-bonded 17 amino acid ring structure. Nesiritide binds to the Atype natriuretic peptide receptor on the surface of endothelial and smooth muscle cells stimulating production of the second messenger cGMP which mediates predominantly vascular smooth muscle cell relaxation. It also facilitates the elimination of sodium and water by the kidney and decreases the secretion of certain hormones, such as adrenalin, angiotensin II, aldosterone and endothelin, which provoke long-term detrimental effects including blood vessel constriction and blood pressure elevation. In clinical trials with heart failure patients, nesidtide dose-dependently reduced pulmonary capillary wedge pressure, right atrial pressure and systemic vascular resistance and increased cardiac index without affecting heart rate. The major adverse effect observed was dose-dependent hypotension. In a phase III comparative trial, nesiritide was found to be superior to iv. nitroglycerine in its haemodynamic effects as well as easier to administer and better tolerated. Nesiritide is cleared by proteolytic cleavage by the enzyme neutral endopeptidase NEP24.11 and by binding to the C-type natriuretic peptide receptor followed by endocytosis and intracellular lysosomal hydrolysis. Since it has a short half-life (18 min), nesiritide is administered as a 21μg/kg bolus infusion followed by a continuous maintenance infusion at 0.011μg/kg/min usually over 24-48 hours.

Verwenden

Treatment of congestive heart failure (renin-angiotensin system antagonist).

Allgemeine Beschreibung

The gene encoding brain natriuretic peptide-32 (BNP-32) is localized on human chromosome 1p36.22. It is implicated in several biological functions such as diuresis, natriuresis, hypotensive action and inhibition of aldosterone secretion. BNP-32 acts as a potential biomarker of high left ventricular-diastolic pressure in patients with symptomatic left ventricular (LV) dysfunction. Elevated expression of this protein is observed in acute myocardial infarction (AMI) patients.

BNP-32 (HUMAN) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


BNP-32 (HUMAN) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 134)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
+86-13017695106 +86-13676922317
jiuyitime@fdachem.com China 16512 58
Sinoway Industrial co., ltd.
+86-0592-5800732 +86-13806035118
xie@china-sinoway.com China 1369 58
Adachibio Inc.
+81-8027837258; +8108027837258
sales@adachibio.com Japan 938 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715
admin@nexconn.com China 10403 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63687 58
Cellmano Biotech Limited
0551-65326643 18156095617
info@cellmano.com China 995 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49979 58
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10236 58

124584-08-3()Verwandte Suche:


  • Nesiritide [USAN:INN]
  • SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (DISULFIDE BRIDGE: 10-26)
  • SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS
  • H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH
  • H-SER-PRO-LYS-MET-VAL-GLN-GLY-SER-GLY-CYS-PHE-GLY-ARG-LYS-MET-ASP-ARG-ILE-SER-SER-SER-SER-GLY-LEU-GLY-CYS-LYS-VAL-LEU-ARG-ARG-HIS-OH (DISULFIDE BRIDGE: 10-26)
  • BRAIN NATRIURETIC PEPTIDE (1-32), HUMAN
  • BRAIN(B-TYPE) NATRIURETIC PEPTIDE-32 (HUMAN)
  • BRAIN NATRIURETIC PEPTIDE, HUMAN
  • BRAIN NATRIURETIC PEPTIDE-32 (HUMAN)
  • B-TYPE (BRAIN) NATRIURETIC PEPTIDE-32 (HUMAN)
  • BNP HUMAN
  • BNP-32 (HUMAN)
  • BNP (1-32), HUMAN
  • BNP-32 (huMan) Brain Natriuretic Peptide-32 (huMan), Nesiritide
  • Brain Natriuretic Peptide-32 (huMan), Nesiritide
  • H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His-OH Acetate salt (Disulfide bond)
  • Nesiritide,Brain Natriuretic Peptide-32 human,BNP-32, >98%
  • BNP-32 (human) hydrochloride
  • Nesiritide (BNP-32)
  • Brain Natriuretic Peptide (BNP) (1-32), human
  • L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-,...
  • BNP-32 (HUMAN) USP/EP/BP
  • Brain natriuretic pe
  • 124584-08-3 Nesiritide [USAN:INN]
  • Nesiritide,Brain Natriuretic Peptide-32 human,BNP-32
  • Nesiritide TFA
  • L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L-arginyl-L-lysyl-L-methionyl-L-α-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-, cyclic (10→26)-disulfide
  • Nesiritide
  • 124584-08-3
  • C143H224N50O42S4
  • Peptides
  • Natriuretic Peptides
  • Amino Acids and Peptides
  • BioChemical
  • Biochemicals and Reagents
  • Elisa Kit-Mouse Elisa Kit
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