Triamcinolon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
A natural extension of corticoid research involved examination of compounds containing both a 9α-fluoro group
and a double bond between positions 1 and 2. Triamcinolone (9-fluoro-11β, 16α, 17, 21-tetrahydroxypregna-
1,4-diene-3,20-dione), introduced in 1958, combines the structural features of a 1
-corticoid and a 9α-fluoro
corticoid. As mentioned previously, the 9α-fluoro group increases the anti-inflammatory potency,
but it also markedly increases the mineralocorticoid potency. This is undesirable if the drug is to be used
internally for the treatment of rheumatoid arthritis. By inserting a 16α-hydroxy group into the molecule, one can
decrease the mineralocorticoid activity.
Chemische Eigenschaften
White, crystalline powder. Insoluble in water; slightly soluble in usual
organic solvents; soluble in dimethylformamide.
Verwenden
Triamcinolone is a glucocorticoid. Triamcinolone is used as an antiasthmatic (inhalant); antiallergic (nasal).
Definition
ChEBI: A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9.
sed in the form of its 16,17-acetonide to treat various skin infections.
Indications
Intralesional bleomycin, a cytotoxic drug that inhibits DNA synthesis, is effective
for all varieties of recalcitrant warts. Various concentrations of the drug have
been used, although the total dose must be carefully tracked over time to avoid
potential systemic toxicity.
Clinical Use
Triamcinolone to be used topically is generally dispensed as its more potent and lipophilic acetonide, a
16α,17α-methylenedioxy cyclic ketal or isopropylidene derivative. It is effective in the treatment of psoriasis and other corticoid-sensitive dermatologic
conditions. Topically, triamcinolone acetonide is a more potent derivative of triamcinolone and is approximately
eight times more active than prednisolone.
Nebenwirkungen
Even though triamcinolone has an apparently decreased tendency to cause salt and water retention and edema
and may induce sodium and water diuresis, it causes other unwanted side effects, including anorexia, weight
loss, muscle weakness, leg cramps, nausea, dizziness, and a general toxic feeling.
Sicherheitsprofil
Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. Human mutation data reported.When heated to decomposition it emits toxic fumes of F.An anti-inflammatory and antiallergic agent.
Triamcinolon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
