Aliskiren hemifumarate
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- CAS-Nr.
- 173334-58-2
- Englisch Name:
- Aliskiren hemifumarate
- Synonyma:
- ALISKIREN FUMARATE;HSDB 7272;CCRIS 9267;Unii-C8A0p8G029;skiren heMifuMarate;Rasilez HeMifuMarate;SPP 100 hemifumarate;Aliskiren Hemifumara;Tekturna HeMifuMarate;Aliskiren hemifumarate
- CBNumber:
- CB21471023
- Summenformel:
- C30H53N3O6
- Molgewicht:
- 551.75832
- MOL-Datei:
- 173334-58-2.mol
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Aliskiren hemifumarate Eigenschaften
- Schmelzpunkt:
- 72-75C
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White
- InChIKey
- UXOWGYHJODZGMF-LRQZUIEYNA-N
- SMILES
- c1(OCCCOC)cc(C[C@H](C(C)C)C[C@@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)ccc1OC |&1:10,15,17,20,r|
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| H360 |
Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Fertility (Fruchtbarkeit) |
Kategorie 1 |
Achtung |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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Aliskiren hemifumarate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Aliskiren hemifumarate (Tekturna(R)) was the first renin inhibitor approved by FDA in March 2007, and genomic analysis validated that Pgx-based dosing guidelines are not required for this drug. The once-daily, oral, direct renin inhibitor received FDA approval for treatment of high blood pressure as mono therapy or in combination with other antihypertensive medications. Furthermore, aliskiren demonstrated increased efficacy when used in combination with other commonly used blood pressure-lowering medications. Novartis is conducting a large outcome trial program to evaluate the long-term effects of aliskiren and of direct renin inhibition in general.
Chemische Eigenschaften
white to slightly yellowish crystalline powder. It is soluble in phosphate buffer, n-Octanol, and highly soluble in water.
Verwenden
Aliskiren hemifumarate is a potent renin inhibitor (IC50 = 0.6 and 80 nM for human and rat respectively). It has antihypertensive activity, decreasing plasma renin activity and inhibiting the conversion of angiotensinogen to Angiotensin I by binding to the S3 sub-pocket of renin. Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.
Aliskiren hemifumarate (ALS) has been used to treat hypertension, alone or with other antihypertensive medications. It is suitable for oral administration. ALS regulates baseline systolic and diastolic blood pressure by blocking the catalytic activity of renin system at its rate-limiting step.
Definition
ChEBI: Aliskiren fumarate is the hemifumarate salt of aliskiren. It has a role as an antihypertensive agent. It contains an aliskiren.
Aliskiren hemifumarate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Aliskiren hemifumarate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 275)Lieferanten
173334-58-2()Verwandte Suche:
Bisoprolol fumarate
Fumarsure
Anisol
(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride
POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE
4,9-Dihydro-4-(1-methylpiperidin-4-yliden)-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-onfumarat
(Trifluormethoxy)benzol
(2S,4S,5S,7S)-7-(3-(3-Methoxypropoxy)-4-methoxybenzyl)-5-amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hydrochloride
4-Methoxyphenol
3,6-Bis[(4-chlor-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalin-2,7-disulfonsure
Anisaldehyd
Dimethylfumarat
Eisen(II)fumarat
Isopropyllaurat
4-Methoxy-anilin
Aminocapronsure
Glycin
ALTRENOGEST
- (2S,4S,5S,7S)-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-8-methylnonanamide hemifumarate
- Aliskiren hemifumarate
(2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide hemifumarate
- (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide hemifumarate
- Benzeneoctanamide, delta-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-gamma-hydroxy-4-methoxy-3-(3-methoxypropoxy)-alpha,zeta-bis(1-methylethyl)-, (alphas,gammas,deltas,zetas)-, (2E)-2-butenedioate (2:1) (salt)
- Aliskiren hemifumarate
- Unii-C8A0p8G029
- (αS,γS,δS,zS)-δ-AMino-N-(3-aMino-2,2-diMethyl-3-oxopropyl)-γ-hydroxy-4-Methoxy-3-(3-Methoxypropoxy)-α,z-bis(1-Methylethyl)benzeneoctanaMide HeMifuMarate
- Rasilez HeMifuMarate
- Tekturna HeMifuMarate
- skiren heMifuMarate
- CCRIS 9267
- HSDB 7272
- (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumarate
- Benzeneoctanamide, δ-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)-, (αS,γS,δS,ζS)-, (2E)-2-butenedioate (2:1)
- Aliskiren hemifumerate
- Aliskiren hemifumarate USP/EP/BP
- Aliskiren Hemifumarate (CGP 60536)
- Aliskiren CAS 173334-58-2
- (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide hemifumarate
- Aliskiren hemifumarate CAS NO.173334-58-2
- CGP 60536 hemifumarate
- CGP60536B hemifumarate
- SPP 100 hemifumarate
- Alicran-d6 (semi-fumarate)
- Aliskiren hemifumarate, 10 mM in DMSO
- Aliskiren hemifumarate - Bio-X ?
- (alphaS,gammaS,deltaS,Zetas)-delta-amino-N-(3-amino-2,2-dimethyl-3-oxo-propyl)-gamma-hydroxy-4-methoxy-3-(3-methoxy-propoxy)-alpha,zeta-bisisopropylbenzeneoctanamide fumarate (2:1)
- Aliskiren Hemifumara
- ALISKIREN FUMARATE
- 173334-58-2
- 17334-58-2
- 246815-96-2
- C30H53N3O612C4H4O4
- 2C30H53N3O6C4H4O4
- C32H55N3O8
- C64H110N6O16
- Cardiovascular APIs
- Amines
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
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