Cilnidipine
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- CAS-Nr.
- 132203-70-4
- Englisch Name:
- Cilnidipine
- Synonyma:
- CiL;clinidipine;ATELEC;CINALONG;SISCARD;FRC-8653;FRG 8653;Sidipine;nidipine;ilnidipine
- CBNumber:
- CB2193117
- Summenformel:
- C27H28N2O7
- Molgewicht:
- 492.52
- MOL-Datei:
- 132203-70-4.mol
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Cilnidipine Eigenschaften
- Schmelzpunkt:
- 97-99°C
- Siedepunkt:
- 652.6±55.0 °C(Predicted)
- Dichte
- 1.240±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- H2O: ≤2mg/mL
- pka
- 2.61±0.70(Predicted)
- Aggregatzustand
- powder
- Farbe
- light yellow
- Wasserl?slichkeit
- H2O: ≤2mg/mL
DMSO: ≥20mg/mL
- Merck
- 14,2275
- InChI
- 1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
- InChIKey
- KJEBULYHNRNJTE-DHZHZOJOSA-N
- SMILES
- C1(C)NC(C)=C(C(OC/C=C/C2=CC=CC=C2)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OCCOC)=O
- CAS Datenbank
- 132203-70-4(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
41 |
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| S-S?tze: |
26-39 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
US7975550 |
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| HS Code |
29333990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Hazard Classifications |
Eye Dam. 1 |
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| Toxizit?t |
LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H318 |
Verursacht schwere Augensch?den. |
Schwere Augensch?digung |
Kategorie 1 |
Achtung |
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P280, P305+P351+P338, P310 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Cilnidipine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cilnidipine is a dihydropyridine calcium antagonist introduced for the
treatment of essential and severe hypertension and hypertension associated with
renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium
channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for
long-term treatment, due to its characteristics of slow onset and long duration with less
cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity.
It may also be useful in ischemic heart disease.
Chemische Eigenschaften
Yellow Crystalline Solid
Verwenden
Cilnidipine has been used:
- in cell viability assay of pheochromocytoma (nPC12) cells
- in photoirradiation and photodegradation studies
- to understand effect on albuminuria in diabetic nephropathy
Definition
ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
Biologische Aktivit?t
Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.
Cilnidipine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Cilnidipine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 504)Lieferanten
132203-70-4()Verwandte Suche:
- (+/-)-(e)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
- O3-(2-Methoxyethyl) O5-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-(2-methoxyethyl)5-[(E)-3-phenyl-2-propenyl] ester
- 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-(2-methoxyethyl)5-[(E)-3-phenyl-2-propenyl] ester
- Frc 8653,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester
2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
- ilnidipine
- 3-CinnaMyl 5-(2-Methoxyethyl) 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 3-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylat
- 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-METHOXYETHYL (2E)-3-PHENYL-2-PROPENYL ESTER
- SISCARD
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester
- 3-Cinnamyl 5-(2-methoxyethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxy
- CILNIDIPINE
- FRC-8653
- CILNDIPINE
- (e)-(+-)-ethoxyethyl3-phenyl-2-propenyleste
- 5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-2-m
- Cinildipine
- CINILDPINE
- Cinidipine
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl Ester, FRC-8653, Atelec, Cinalong, Siscard,
- CILNIDPINE
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 3-phenyl-2-propenyl ester, (E)-(+-)-
- FRG 8653
- Cilnidipine and intermediates
- 2,6-dimethyl-4-(3-nitrophenyl)-5-(3-phenylprop-2-enoxymethyl)-1,4-dihydropyridine-3-carboxylic acid 2-methoxyethyl ester
- Sidipine
- Cilnidipine (FRC-8653)
- Cilnidipine Whatsapp
- Cilnidipine >
- Cilnidipine RS
- nidipine
- 2-Methoxyethyl (2E)-3-Phenyl-2-propenyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
- Cilnidipine USP/EP/BP
- CilnidipineQ: What is
Cilnidipine Q: What is the CAS Number of
Cilnidipine Q: What is the storage condition of
Cilnidipine
- Cilnidipine D4
- ATELEC
- CINALONG
- 13C6]-Cilnidipine
- Cilinidipine
- Cilnidipine, ≥ 98.0%
- Cilnidipine, Dual L- and N-type Ca2+ channel blocker
- Cilnidipine, 10 mM in DMSO
- Cilnidipine - Bio-X ?
- CiL
- clinidipine
- 132203-70-4
- 132229-17-9
- Dihydropyridine Class Chemicals
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Calcium channel
- API
- FRC 8653
- Dihydropyridine
