Cilnidipine is a dihydropyridine calcium antagonist introduced for the
treatment of essential and severe hypertension and hypertension associated with
renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium
channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for
long-term treatment, due to its characteristics of slow onset and long duration with less
cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity.
It may also be useful in ischemic heart disease.
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Yellow Crystalline Solid
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Cilnidipine has been used:
in cell viability assay of pheochromocytoma (nPC12) cells
in photoirradiation and photodegradation studies
to understand effect on albuminuria in diabetic nephropathy
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ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
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Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.
