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17-PHENYL TRINOR PGF2ALPHA-IPR

17-PHENYL TRINOR PGF2ALPHA-IPR Struktur
130209-76-6
CAS-Nr.
130209-76-6
Englisch Name:
17-PHENYL TRINOR PGF2ALPHA-IPR
Synonyma:
Bimatoprost isopropyl ester;13-trans-Latanoprost;Sparsentan Impurity 17;Bimatoprost isopropyl este;imatoprost isopropyl ester;17-PHENYL TRINOR PGF2ALPHA-IPR;Bimatoprost Acid Isopropyl Ester;17-phenyl trinor PGF2α isopropyl ester;17-phenyl trinor PGF2alpha isopropyl ester;17-phenyl trinor Prostaglandin F2α isopropyl ester
CBNumber:
CB2459437
Summenformel:
C26H38O5
Molgewicht:
430.58
MOL-Datei:
130209-76-6.mol

17-PHENYL TRINOR PGF2ALPHA-IPR Eigenschaften

Siedepunkt:
573.4±50.0 °C(Predicted)
Dichte
1.141
storage temp. 
Store at -20°C
L?slichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 1 mg/ml
pka
14.25±0.20(Predicted)
Aggregatzustand
Solid
Farbe
White to off-white
InChIKey
JGZRPRSJSQLFBO-FWPUOYPASA-N
SMILES
C(OC(C)C)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCC1=CC=CC=C1
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) Health Hazard (GHS08)Exclamation Mark (GHS07)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H360 Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
Sicherheit

17-PHENYL TRINOR PGF2ALPHA-IPR Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

17-phenyl trinor PGF N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF isopropyl ester derivative was examined for IOP-lowering activity during the development of latanoprost. At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.

17-PHENYL TRINOR PGF2ALPHA-IPR Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


17-PHENYL TRINOR PGF2ALPHA-IPR Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 17-phenyl-18,19,20-trinor-prostaglandinf2alpha-1-isopropylester
  • 9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
  • 17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER
  • 17-PHENYL TRINOR PGF2ALPHA-IPR
  • 7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-5-heptenoic acid 1-methylethyl ester
  • 17-phenyl trinor Prostaglandin F2α isopropyl ester
  • 17-phenyl trinor PGF2α isopropyl ester
  • isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate
  • (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-5-heptenoic acid propan-2-yl ester
  • propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoate
  • Bimatoprost isopropyl este
  • imatoprost isopropyl ester
  • 17-phenyl trinor PGF2alpha isopropyl ester
  • Bimatoprost Acid Isopropyl Ester
  • 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z)-
  • 13-trans-Latanoprost
  • isopropyl phenylhydroxypentene dihydroxycyclopentylheptenate
  • Sparsentan Impurity 17
  • Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate
  • 17-phenyl trinor Prostaglandin F2α isopropyl ester
  • Bimatoprost isopropyl ester
  • 130209-76-6
  • C26H38O5
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