デヒドロラタノプロスト
デヒドロラタノプロスト 物理性質(zhì)
- 沸點(diǎn) :
- 573.4±50.0 °C(Predicted)
- 比重(密度) :
- 1.141
- 貯蔵溫度 :
- Store at -20°C
- 溶解性:
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 1 mg/ml
- 酸解離定數(shù)(Pka):
- 14.25±0.20(Predicted)
- 外見 :
- Solid
- 色:
- White to off-white
- InChIKey:
- JGZRPRSJSQLFBO-FWPUOYPASA-N
- SMILES:
- C(OC(C)C)(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCC1=CC=CC=C1
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
デヒドロラタノプロスト 価格
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購(gòu)入 |
デヒドロラタノプロスト 化學(xué)特性,用途語(yǔ),生産方法
説明
17-
phenyl trinor PGF
2α N-
ethyl amide is an F-
series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost. The N-
ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost. This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-
phenyl trinor PGF
2α, is a potent FP receptor agonist. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-
phenyl trinor PGF
2α isopropyl ester derivative was examined for IOP-
lowering activity during the development of latanoprost. At the dose of 3 μg/eye in the monkey, 17-
phenyl trinor PGF
2α isopropyl ester was the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative was also significantly more irritating to the eye than latanoprost.
デヒドロラタノプロスト 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
デヒドロラタノプロスト 生産企業(yè)
Global( 62)Suppliers
130209-76-6(デヒドロラタノプロスト)キーワード:
- 130209-76-6
- 17-phenyl-18,19,20-trinor-prostaglandinf2alpha-1-isopropylester
- 9ALPHA,11ALPHA,15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROSTA-5Z,13E-DIEN-1-OIC ACID, ISOPROPYL ESTER
- 17-PHENYL TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER
- 17-PHENYL TRINOR PGF2ALPHA-IPR
- 7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-5-heptenoic acid 1-methylethyl ester
- 17-phenyl trinor Prostaglandin F2α isopropyl ester
- 17-phenyl trinor PGF2α isopropyl ester
- isopropyl 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate
- (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-5-heptenoic acid propan-2-yl ester
- propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]hept-5-enoate
- Bimatoprost isopropyl este
- imatoprost isopropyl ester
- 17-phenyl trinor PGF2alpha isopropyl ester
- Bimatoprost Acid Isopropyl Ester
- 5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-, 1-methylethyl ester, (5Z)-
- 13-trans-Latanoprost
- isopropyl phenylhydroxypentene dihydroxycyclopentylheptenate
- Sparsentan Impurity 17
- Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)hept-5-enoate
- 17-phenyl trinor Prostaglandin F2α isopropyl ester
- Bimatoprost isopropyl ester
- デヒドロラタノプロスト