Pomalidomide-PEG1-azide

2133360-04-8

CAS-Nr.: 2133360-04-8

Englisch Name:: Pomalidomide-PEG1-azide

Synonyma:: N3-PEG1-CH2CO-Poma;Pomalidomide-PEG1-azide;Pomalidomide-NH-CO-PEG1-N3;2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]acetamide;2-(2-azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide;2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide;Acetamide, 2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;2-(2-Azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG1-azide;Pomalidomide-PEG1-azide/Acetamide,2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-

CBNumber:: CB24813989

Summenformel:: C17H16N6O6

Molgewicht:: 400.35

MOL-Datei:: 2133360-04-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 27

Pomalidomide-PEG1-azide Eigenschaften

storage temp.: 2-8°C

L?slichkeit: DMSO : 62.5 mg/mL (156.11 mM; ultrasonic and warming and heat to 60°C)

Aggregatzustand: Solid

Farbe: Light yellow to yellow

InChIKey: SKTGGMFEGRISBY-UHFFFAOYSA-N

SMILES: O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCN=[N+]=[N-])=O)=O)NC1=O

Sicherheit

WGK Germany	WGK 3
Speicherklasse	11 - Combustible Solids

Pomalidomide-PEG1-azide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block Pomalidomide-PEG1-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG1-azide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pomalidomide-PEG1-azide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 27)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068	1924344760@confluore.cn	China	2997	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	89686	60
Shanghai Chaolan Chemical Technology Center	QQ：65489617 19372819560	Sales@ATKchemical.com	China	9627	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4952	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1639	58
Changsha Bono New Materials Technology Co., Ltd.	18191076804	asherw9@hotmail.com	China	2373	58

Pomalidomide-PEG1-azide
Pomalidomide-NH-CO-PEG1-N3
2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]acetamide
N3-PEG1-CH2CO-Poma
Acetamide, 2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
2-(2-Azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide?, Pomalidomide-PEG1-azide
Pomalidomide-PEG1-azide/Acetamide,2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]acetamide
2-(2-azidoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)acetamide
2133360-04-8
peg

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