ChemicalBook >?? ???? >Pomalidomide-PEG1-azide
Pomalidomide-PEG1-azide
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Pomalidomide-PEG1-azide ??
- ?? ??
- 2-8°C
- ???
- DMSO : 62.5 mg/mL (156.11 mM; ultrasonic and warming and heat to 60°C)
- ??? ??
- Solid
- ??
- Light yellow to yellow
- InChIKey
- SKTGGMFEGRISBY-UHFFFAOYSA-N
- SMILES
- O=C(C(CC1)N(C2=O)C(C3=C2C=CC=C3NC(COCCN=[N+]=[N-])=O)=O)NC1=O
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| WGK ?? | WGK 3 | ||
|---|---|---|---|
| ???? ??? | 11 - Combustible Solids |
Pomalidomide-PEG1-azide C??? ??, ??, ??
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Protein degrader builiding block Pomalidomide-PEG1-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Pomalidomide-PEG1-azide ?? ?? ? ???
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Pomalidomide-PEG1-azide ?? ??
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| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32468 | 58 |
| BOC Sciences | 16314854226; +8616314854226 |
inquiry@bocsci.com | United States | 19853 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 |
1924344760@confluore.cn | China | 2997 | 58 |
| Aladdin Scientific | |
tp@aladdinsci.com | United States | 57505 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 |
shyysw007@163.com | China | 89686 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 |
Sales@ATKchemical.com | China | 9650 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 |
1924344760@qq.com | China | 4142 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 |
1927928688@qq.com | China | 1643 | 58 |
| Changsha Bono New Materials Technology Co., Ltd. | 18191076804 |
asherw9@hotmail.com | China | 2373 | 58 |
Pomalidomide-PEG1-azide ?? ??:
Pomalidomide-PEG3-N3
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Pomalidomide-PEG5-CO2H
E3 ligase Ligand-Linker Conjugates 50
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Pomalidomide-PEG4-CO2H
E3 Ligase Ligand-Linker Conjugates 1
POMALIDOMIDE-PEG1-CO2H
Pomalidomide-O-C4-NH2
Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
Pomalidomide-PEG6-butyl iodide
Pomalidomide-PEG2-N3
Pomalidomide-NH-CO-PEG6-N3
Pomalidomide-PEG5-N3