GSK-3BETA INHIBITOR XII
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- CAS-Nr.
- 601514-19-6
- Englisch Name:
- GSK-3BETA INHIBITOR XII
- Synonyma:
- TWS119;TWS11;TWS S;CS-445;CS-1924;TWS119, >=98%;TWS-119; TWS 119;OTAVA-BB 7070707013;TWS119, 10 mM in DMSO;GSK-3BETA INHIBITOR XII
- CBNumber:
- CB2803764
- Summenformel:
- C18H14N4O2
- Molgewicht:
- 318.33
- MOL-Datei:
- 601514-19-6.mol
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GSK-3BETA INHIBITOR XII Eigenschaften
- Schmelzpunkt:
- 249 °C
- Dichte
- 1.42
- storage temp.
- 2-8°C
- L?slichkeit
- insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
- Aggregatzustand
- powder
- pka
- 8.99±0.10(Predicted)
- Farbe
- white to beige
- InChI
- 1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
- InChIKey
- VPVLEBIVXZSOMQ-UHFFFAOYSA-N
- SMILES
- OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
GSK-3BETA INHIBITOR XII Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.
Allgemeine Beschreibung
A cell-permeable and potent inhibitor of GSK-3β (IC
50 = 30 nM). Binds to GSK-3β with high-affinity (K
d = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).
Biologische Aktivit?t
Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
GSK-3BETA INHIBITOR XII Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GSK-3BETA INHIBITOR XII Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 173)Lieferanten
- GSK-3BETA INHIBITOR XII
- 3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL
- OTAVA-BB 7070707013
- 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate
- 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119
- TWS 119 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
- GSK-3β Inhibitor, TWS119
- TWS119, >=98%
- TWS11
- GSK-3β Inhibitor XII, TWS119
- CS-1924
- TWS-119; TWS 119
- CS-445
- TWS 119 (This product is unavailable in the U.S.)
- TWS S
- Phenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-
- GSK-3BETA INHIBITOR XII USP/EP/BP
- TWS119, GSK-3beta inhibitor
- TWS119, 10 mM in DMSO
- GSK-3β Inhibitor XII, TWS119
- TWS119
- 601514-19-6
- C18H14N4O22CF3CO2H
- Akt
- mTOR
- PI3K
- Inhibitors
