TWS 119
TWS 119 物理性質(zhì)
- 融點(diǎn) :
- 249 °C
- 比重(密度) :
- 1.42
- 貯蔵溫度 :
- 2-8°C
- 溶解性:
- insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
- 外見 :
- 粉
- 酸解離定數(shù)(Pka):
- 8.99±0.10(Predicted)
- 色:
- 白からベージュ
- InChI:
- 1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
- InChIKey:
- VPVLEBIVXZSOMQ-UHFFFAOYSA-N
- SMILES:
- OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
| メーカー |
製品番號(hào) |
製品説明 |
CAS番號(hào) |
包裝 |
価格 |
更新時(shí)間 |
購入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01W0120-1767 |
90.0+% (HPLC)
TWS119 90.0+% (HPLC) |
601514-19-6 |
1mg |
￥8150 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式會(huì)社(wako)
|
W01W0120-1767 |
90.0+% (HPLC)
TWS119 90.0+% (HPLC) |
601514-19-6 |
5mg |
￥24300 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
T3605 |
TWS 119 >95.0%(HPLC)
TWS 119 (This product is unavailable in the U.S.)
>95.0%(HPLC) |
601514-19-6 |
5mg |
￥12100 |
2024-03-01 |
購入 |
|
東京化成工業(yè)
|
T3605 |
TWS 119 >95.0%(HPLC)
TWS 119 (This product is unavailable in the U.S.)
>95.0%(HPLC) |
601514-19-6 |
25mg |
￥42500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML1271 |
≥98% (HPLC)
TWS119 ≥98% (HPLC) |
601514-19-6 |
5mg |
￥22400 |
2024-03-01 |
購入 |
TWS 119 化學(xué)特性,用途語,生産方法
外観
白色?褐色, 結(jié)晶性粉末?粉末
使用
Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.
一般的な説明
A cell-permeable and potent inhibitor of GSK-3β (IC
50 = 30 nM). Binds to GSK-3β with high-affinity (K
d = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).
生物活性
Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
TWS 119 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
TWS 119 生産企業(yè)
Global( 174)Suppliers
601514-19-6(TWS 119)キーワード:
- 601514-19-6
- GSK-3BETA INHIBITOR XII
- 3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL
- OTAVA-BB 7070707013
- 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate
- 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119
- TWS 119 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
- GSK-3β Inhibitor, TWS119
- TWS119, >=98%
- TWS11
- GSK-3β Inhibitor XII, TWS119
- CS-1924
- TWS-119; TWS 119
- CS-445
- TWS 119 (This product is unavailable in the U.S.)
- TWS S
- Phenol, 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-
- GSK-3BETA INHIBITOR XII USP/EP/BP
- TWS119, GSK-3beta inhibitor
- TWS119, 10 mM in DMSO
- GSK-3β Inhibitor XII, TWS119
- TWS119
- TWS 119
- TWS-119
- 3-[6-(3-アミノフェニル)-7H-ピロロ[2,3-d]ピリミジン-4-イルオキシ]フェノール
- 3-{[6-(3-アミノフェニル)-7H-ピロロ[2,3-d]ピリミジン-4-イル]オキシ}フェノール