AMG 925 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC₅₀s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC₅₀ = 2.22 μM). AMG 925 also binds to FLT3^ITD, FLT3^D835Y, FLT3^D835H, FLT3^K663Q, and FLT3^N841I (K_ds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC₅₀s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.

AMG 925 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AMG 925 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
Aladdin Scientific		tp@aladdinsci.com	United States	57473	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238	sales@sun-shinechem.com	China	1197	64
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4764	58
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9512	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61

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• AMG 925
• 1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone
• 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-
• Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy-
• AMG 925;AMG925;AMG-925
• CS-1594
• 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone
• AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.
• FLX 925.
• FLX925
• FLX-925
• AMG 925 (FLX925
• FLX925 (AMG-925)
• CDK,AMG 925,Cluster of differentiation antigen 135,FLT3,Cyclin dependent kinase,inhibit,CD135,AMG-925,AMG925,Inhibitor,Fms like tyrosine kinase 3
• 1401033-86-0
• C26H29N7O2