AMG 925
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AMG 925 ??
- ?? ?
- 712.3±70.0 °C(Predicted)
- ??
- 1.48±0.1 g/cm3(Predicted)
- ?? ??
- Store at -20°C
- ???
- insoluble in DMSO; insoluble in H2O; insoluble in EtOH
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 13.41±0.10(Predicted)
- ??
- Light yellow to yellow
??
AMG 925 C??? ??, ??, ??
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AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 μM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC50s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.AMG 925 ?? ?? ? ???
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2,4-Pyrimidinediamine, N4-(trans-4-methylcyclohexyl)-
1401033-82-6
2,4-Pyrimidinediamine, 5-iodo-N4-(trans-4-methylcyclohexyl)-
9H-Pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine, 9-(trans-4-methylcyclohexyl)-
2-methylpropan-2-yl 2-({9-[(1r,4r)-4-methylcyclohexyl]pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-5,6,7,8-tetrahydropyrido[4,3-b]pyridine-6-carboxylate
???-4-??????????
tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
???-4-????????????
2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-????????
????
??????
?? ??
AMG 925 ?? ??
???( 81)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32467 | 58 |
| BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; |
support@targetmol.com | United States | 39040 | 58 |
| Aladdin Scientific | |
tp@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131956 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 18971495150; |
sales@sun-shinechem.com | China | 1171 | 64 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 |
sales@meilune.com | China | 4794 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 |
info@topbiochem.com | China | 9520 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 |
info@chemexpress.com | China | 7552 | 61 |