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Selank peptide

Selank peptide Struktur
129954-34-3
CAS-Nr.
129954-34-3
Englisch Name:
Selank peptide
Synonyma:
SELANK;SLANK;L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline;L-THREONYL-L-LYSYL-L-PROLYL-L-ARGINYL-L-PROLYLGLYCYL-L-PROLINE; MONOACETATE;Selanc;PL14736;Selank CAS;C33H57N11O9;Salbu Sulfate;Selank peptid
CBNumber:
CB33161651
Summenformel:
C33H57N11O9
Molgewicht:
751.87
MOL-Datei:
129954-34-3.mol

Selank peptide Eigenschaften

Schmelzpunkt:
134-136 °C
Dichte
1.53±0.1 g/cm3(Predicted)
pka
3.43±0.20(Predicted)
Sequenz
Thr-Lys-Pro-Arg-Pro-Gly-Pro
InChIKey
JTDTXGMXNXBGBZ-YVHUGQOKSA-N
SMILES
C(O)(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H]([C@H](O)C)N

Sicherheit

Selank peptide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Selank is a synthetic derivative of the tetrapeptide tuftsin that contains a proline-glycine-proline sequence at the C-terminus and has anxiolytic and anti-inflammatory activities. It increases the amplitude and discharge rate of inhibitory postsynaptic currents of neurons in the rat hippocampal CA1 region when used at a concentration of 1 μM. It decreases the level of affective responses and the number of erroneous escape attempts in rats in an acute stress situation, increases orientational-investigative responses of rats in an unfamiliar situation, and reduces the time mice spend immobile in the forced swim test. It increases locomotor activity of high-anxiety Balb/c, but not C57Bl/6, mice in the open field test. Selank (0.01 mg/kg) decreases verticalization induced by apomorphine in mice. It also decreases expression of the inflammation-related genes Il2rg and Xcr1 in mouse spleen after 90 minutes when administered at a dose of 100 μg/kg.

Verwenden

Selank peptide has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and antistress drug that relieves aggression and fear reaction in different animal species. It is often prescribed for its anxiolytic properties, immune improvement, gastric protection, and with opioid and alcohol withdrawal/ dependence. It also has a nootropic action, which positively influences the formation of memory and learning processes, and marked immunomodulatory activity.

benefits

Selank peptide has the following benefits: It improves anxiety and stress reactions. Enhances memory and learning. Strengthens immune function by increasing inflammatory proteins to help fight infections. Increases BDNF (brain-derived neurotrophicfactor) - a vital brain-growth compoundrelated to learning and memory. Prevent weight gain and reduce cholesterol. Decreases alcohol-withdrawal-related anxiety. Decreased blood pressure and increased brain blood flow. Helps to increase lymph flow to the stomach and decrease stomach ulcers. Stabilizes blood enkephalins - natural peptides that can reduce stress.

Mechanism of action

Selank peptide is known that the classical benzodiazepines act via gamma-aminobutyric acid (GABA) type A receptors. They enhance the GABA effect by allosteric modulation, which increases the frequency of opening of channels for chlorine ions. The Selank action mechanism may be related to its ability to affect the performance of the GABAergic system.

Selank peptide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Selank peptide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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129954-34-3()Verwandte Suche:


  • Selank peptide
  • SelankAcetate
  • PL14736
  • H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH
  • Selank peptid
  • L-Proline, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-
  • Lyophilized Powder Peptides Peptide Selank CAS 129954-34-3 5mg/Vial
  • Salbu Sulfate
  • Thr-Lys-PRO-Arg-PRO-Gly-PRO
  • TIANFUCHEM--129954-34-3 ---Selank peptide
  • Selanc
  • Peptides Selank Injection
  • Selank CAS
  • Selankamidate
  • selank 5mg 10mg
  • Selank 5mg 10mg 30mg
  • L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline
  • L-THREONYL-L-LYSYL-L-PROLYL-L-ARGINYL-L-PROLYLGLYCYL-L-PROLINE; MONOACETATE
  • SELANK
  • SLANK
  • C33H57N11O9
  • 129954-34-3
  • C33H57N11O9
  • 129954-34-3
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