一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Eplerenone

Eplerenone Struktur
107724-20-9
CAS-Nr.
107724-20-9
Englisch Name:
Eplerenone
Synonyma:
Inspra;EPLERINONE;Elperenone;Eplerenone CRS;(+)-Eplerenone;Eplerenone [USAN];pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester;PREGNA-4-ENE-7,21-DICARBOXYLIC ACID,11,17-DIHYDROXY-3-OXO,G-LACTONE,METHYLESTER,(7Α,11Α,17Α);(7A,11A,17A)-9,11-EPOXY-17-HYDROXY-3-OXO-PREGN-4-ENE-7,21-DICARBOXYLIC ACID G-LACTONE METHYL ESTER;SC-66110
CBNumber:
CB3489802
Summenformel:
C24H30O6
Molgewicht:
414.49
MOL-Datei:
107724-20-9.mol

Eplerenone Eigenschaften

Schmelzpunkt:
241-243°C
alpha 
D +5° (c = 0.437 in chloroform)
Siedepunkt:
597.9±50.0 °C(Predicted)
Dichte
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
L?slichkeit
DMSO: soluble2mg/mL, clear (warmed)
Aggregatzustand
powder
Farbe
white to beige
maximale Wellenl?nge (λmax)
240nm(lit.)
Merck 
14,3625
Major Application
pharmaceutical
InChIKey
UZZAHAKTLYRDOK-MGIDJNSKSA-N
SMILES
[C@@]123[C@@]4(C)CCC(=O)C=C4C[C@@H](C(OC)=O)[C@@]1([H])[C@]1([H])CC[C@]4(CCC(=O)O4)[C@]1(C[C@@]2([H])O3)C |&1:0,1,10,15,17,21,27,29,r|
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
RIDADR  3077
WGK Germany  3
HS Code  29322090
Speicherklasse 11 - Combustible Solids
Giftige Stoffe Daten 107724-20-9(Hazardous Substances Data)
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Eplerenone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Eplerenone is a mineralocorticoid receptor antagonist. It is selective for the mineralocorticoid receptor over glucocorticoid, androgen, progesterone, and estrogen receptors in radioligand binding assays (IC50s = 138, 6,920, 523, >10,000, and 5,702 nM, respectively). Eplerenone inhibits aldosterone-induced mineralocorticoid activity in a luciferase assay (IC50 = 122 nM). In vivo, eplerenone (100 mg/kg per day) reduces urinary albumin secretion and glomerulosclerosis in the Dahl salt-sensitive rat model of hypertension and nephropathy. It reduces myocardial IL-1β levels and collagen deposition, as well as improves left ventricular systolic dysfunction in a mouse model of acute myocardial infarction. Formulations containing eplerenone have been used in the treatment of hypertension and heart failure after myocardial infarction.

Chemische Eigenschaften

White Solid

Verwenden

Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.

Allgemeine Beschreibung

Eplerenone, 9,11α-epoxy-17α-hydroxy-3-oxopregn-4-ene-7α,21-dicarboxylic acid, γ-lactone,methyl ester (Inspra), is a newer aldosterone antagonist that isused for the treatment of hypertension.

Biologische Aktivit?t

Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo .

Clinical Use

A newer drug, eplerenone, has a structure similar to that of spironolactone and a similar mechanism of action. It was initially approved for use in the treatment of hypertension but it can now be used in the treatment of patients with left ventricular systolic dysfunction and congestive heart failure after myocardial infarction.

Eplerenone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Eplerenone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 561)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Kangcang new material Technology Co., LTD
+8615713292910
Nancy@kangcang.com.cn China 341 58
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
Wuhan Fortuna Chemical Co., Ltd
+86-27-59207850
info@fortunachem.com China 5982 58
Hebei Dangtong Import and export Co LTD
+86-86-4001020630 +8619831957301
admin@hbdangtong.com China 999 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 310 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+86-15350851019; +8615350851019
admin@86-ss.com China 999 58
Shaanxi Xianhe Biotech Co., Ltd
+86-17709210191; +8617709210191
Jerry@xhobio.com China 906 58
Moxin Chemicals
+86-17320513646 +8617320513646
anna@molcoo.com China 10000 58
Wuhan JiyunZen Tech Co., Ltd.
+86-18062099985
Amyjiyunzen@yeah.net China 672 58

107724-20-9()Verwandte Suche:


  • (2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
  • HSDB 7522
  • Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-
  • Eplerenone intermediate Eplerenone
  • (7α,11α,17α)-9,11-epoxy-17-hydroxy-3-oxo-γ-lactone-pregn-4-ene-7,21-dicarboxylic acid-7-methyl ester
  • Eplerenone for system suitability
  • Eplerenone for peak identification
  • EPLERENONE
  • EPLERENONE 98%
  • EPLERENONE USP STANDARD
  • EplerenoneC24H3006
  • (7a,11a,17a)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid -Lactone 7-Methyl Ester
  • CGP 30083
  • SC-66110
  • pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo, γ-lactone, methyl ester (7 α, 11 α, 17 α)
  • EPLERENONE AND N-1 INTERMEDIATE
  • epoxymexrenone
  • CGP 30083, Epoxymexrenone, Inspra, Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2(3-furan],pregn-4-ene-7,21-dicarboxylic Acid, Inspra,
  • (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylicacidγ-lactonemethylester
  • Methyl (1'R,2R,2'S,9'R,10'S,11'S,15'S,17'R)-2',15'-diMethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate
  • (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid
  • γ-Lactone 7-Methyl Ester
  • 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic Acid gamma-Lactone Methyl Ester
  • Eplerenone-13C-d3
  • plerenone
  • Eplerenone, 98%, selective mineralocorticoid antagonist
  • INSPRA;EPOXYMEXRENONE
  • Eplerenone for system suitability CRS
  • Eplerenone for peak identification CRS
  • Eplerenone RS
  • Eplerenone>
  • Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, γ-lactone, 7-methyl ester, (7α,11α,17α)-
  • Eplerenone USP/EP/BP
  • Eplerenone (Epoxymexrenone
  • Eplerenone D3Q: What is Eplerenone D3 Q: What is the CAS Number of Eplerenone D3 Q: What is the storage condition of Eplerenone D3 Q: What are the applications of Eplerenone D3
  • Eplerenone EPQ: What is Eplerenone EP Q: What is the CAS Number of Eplerenone EP Q: What is the storage condition of Eplerenone EP Q: What are the applications of Eplerenone EP
  • Eplerenone (1237553)
  • Eplerenone [USAN]
  • (7A,11A,17A)-9,11-EPOXY-17-HYDROXY-3-OXO-PREGN-4-ENE-7,21-DICARBOXYLIC ACID G-LACTONE METHYL ESTER
  • EPLERINONE
  • pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester
  • Inspra
  • Eplerenone CRS
  • PREGNA-4-ENE-7,21-DICARBOXYLIC ACID,11,17-DIHYDROXY-3-OXO,G-LACTONE,METHYLESTER,(7Α,11Α,17Α)
  • Eplerenone Hormone Raw Powder
  • (2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-methyl 4a,6a-dimethyl-2,5'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
  • Eprolidone
  • Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,4'-dioxo-2,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
  • Eplenone
  • Eplerenone, Selective mineralocorticoid antagonist
  • Eplerenone, 10 mM in DMSO
  • Eplerenone - Bio-X ?
  • Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,4'-dioxo-2,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate
  • (+)-Eplerenone
  • Elperenone
  • 107724-20-9
  • 07724-20-9
  • 107727-20-9
Copyright 2019 ? ChemicalBook. All rights reserved
石景山区| 大厂| 广东省| 涟源市| 高陵县| 花莲县| 莱西市| 丹江口市| 崇信县| 湘乡市| 上饶市| 惠州市| 融水| 湾仔区| 库伦旗| 化德县| 清涧县| 科尔| 惠州市| 庄浪县| 姜堰市| 南和县| 明溪县| 车致| 温泉县| 嘉祥县| 五大连池市| 冕宁县| 镇康县| 乐业县| 福海县| 宁河县| 县级市| 托克逊县| 苏尼特右旗| 宁陵县| 湟源县| 谢通门县| 治多县| 镇宁| 深水埗区|