6-Hydroxy-5-nitronicotinic acid
|
|
|
- CAS-Nr.
- 6635-31-0
- Englisch Name:
- 6-Hydroxy-5-nitronicotinic acid
- Synonyma:
- 135339;6-Hydroxy-5-Nitro Niacin;6-hyroxy-5-nitronicotinic acid;Linaprazan Glurate Impurity 51;6-HYDROXY-5-NITRONICOTINIC ACID;5-Nitro-6-hydroxynicotinic acid;6-Hydroxy-5-nitronicotinicAcid>5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE;6-Hydroxy-5-nitronicotinic acid 97%;6-Hydroxy-5-nitropyridine-3-carboxylicaci
- CBNumber:
- CB3671957
- Summenformel:
- C6H4N2O5
- Molgewicht:
- 184.11
- MOL-Datei:
- 6635-31-0.mol
|
6-Hydroxy-5-nitronicotinic acid Eigenschaften
- Schmelzpunkt:
- 269-271
- Siedepunkt:
- 363.6±42.0 °C(Predicted)
- Dichte
- 1.70±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- Aggregatzustand
- powder to crystal
- pka
- 3.09±0.50(Predicted)
- Farbe
- Light yellow to Yellow
- BRN
- 177986
- InChI
- InChI=1S/C6H4N2O5/c9-5-4(8(12)13)1-3(2-7-5)6(10)11/h1-2H,(H,7,9)(H,10,11)
- InChIKey
- VJMXJGVEVASJOD-UHFFFAOYSA-N
- SMILES
- C1NC(=O)C([N+]([O-])=O)=CC=1C(O)=O
- CAS Datenbank
- 6635-31-0(CAS DataBase Reference)
6-Hydroxy-5-nitronicotinic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
6-Hydroxy-5-nitronicotinic acid is mainly used as an antibacterial agent and pharmaceutical intermediate.
Application
6-Hydroxy-5-nitronicotinic acid serves as a multifunctional building block in medicinal and agrochemical synthesis: it acts as an antimicrobial agent, a pharmaceutical intermediate for vitamin B3 derivatives and other bio-actives, and a lead compound for antitumor, anti-inflammatory, antifungal and antiviral drug discovery.
Chemische Reaktivit?t
6-Hydroxy-5-nitronicotinic acid is stable under proper conditions, it reacts with oxidizing agents.
Synthese
6-Hydroxy-5-nitronicotinic acid is synthesised using 6-Hydroxynicotinic acid as a raw material by chemical reaction. The specific synthesis steps are as follows:
6-Hydroxynicotinic acid 2 (25.0 g, 180 mmol) was dissolved in HNO3 fuming (1.52) (95 mL) and stirred at 50 oC for 18 h. After the solution was cooled to room temperature, the mixture was concentrated, and then co-evaporated with water, followed by the addition of MeOH to afford a brown precipitate. The precipitate was filtered and washed with 50 mL of cold MeOH twice. After drying under reduced pressure, a brown color product 3 was obtained; yield: 9.67 g (29percent); 1H NMR (300 MHz, CD3OD) 8.44 (d, J = 2.6 Hz, 1H), 8.85 (d, J = 2.6 Hz, 1H) ; HRMS (ES+): m/z 185.0194 (M+H+) (calcd for C6H5N2O5: 185.0198).
6-Hydroxy-5-nitronicotinic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-Hydroxy-5-nitronicotinic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 272)Lieferanten
6635-31-0()Verwandte Suche:
- 6-HYDROXY-5-NITRONICOTINIC ACID
- 2-HYDROXY-3-NITRO-5-PYRIDINECARBOXYLIC ACID
- 2-HYDROXY-3-NITROPYRIDINE-5-CARBOXYLIC ACID
- 6-Hydroxy-5-nitronicotinic acid 97%
- 5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE
- 6-hyroxy-5-nitronicotinic acid
- 6-Hydroxy-5-nitropyridine-3-carboxylic acid, 5-Carboxy-2-hydroxy-3-nitropyridine
- 135339
- 6-Hydroxy-5-nitronicotinicAcid>
- 3-Pyridinecarboxylic acid, 1,6-dihydro-5-nitro-6-oxo-
- 6-Hydroxy-5-nitropyridine-3-carboxylicaci
- 6-Hydroxy-5-nitro-3-pyridinecarboxylic Acid
- 6-Hydroxy-5-nitronicotinic acid ISO 9001：2015 REACH
- 6-Hydroxy-5-Nitro Niacin
- 5-Nitro-6-hydroxynicotinic acid
- 6-Hydroxy-5-nitropyridine-3-carboxylic acid, CAS 6635-31-0
- 6-Hydroxy-5-nitropyridin-3-carboxylic acid
- Linaprazan Glurate Impurity 51
- 6635-31-0
- 6365-31-0
- CHIRAL CHEMICALS
- blocks
- Carboxes
- NitroCompounds
- Pyridines
