Micheliolide

68370-47-8

CAS-Nr.: 68370-47-8

Englisch Name:: Micheliolide

Synonyma:: CS-1321;Mecheliolide;Micheliolide;Micheliolide, BR;Micheliolide 68370-47-8;Micheliolide, 10 mM in DMSO;Nuclear factor-κB,NF-κB,inhibit,Micheliolide,Nuclear factor-kappaB,Inhibitor;(3aS)-3aβ,4,5,7,8,9,9aβ,9bα-Octahydro-9β-hydroxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2(3H)-one;(3aS,9R,9aS,9bS)-9-hydroxy-6,9-dimethyl-3-methylidene-4,5,7,8,9a,9b-hexahydro-3aH-azuleno[4,5-b]furan-2-one;Azuleno[4,5-b]furan-2(3H)-one, 3a,4,5,7,8,9,9a,9b-octahydro-9-hydroxy-6,9-dimethyl-3-methylene-, (3aS,9R,9aS,9bS)-

CBNumber:: CB42339810

Summenformel:: C15H20O3

Molgewicht:: 248.32

MOL-Datei:: 68370-47-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 126

Micheliolide Eigenschaften

Schmelzpunkt:: 131-133 °C

Siedepunkt:: 426.1±45.0 °C(Predicted)

Dichte: 1.17±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

L?slichkeit: Chloroform (Slightly), Methanol (Slightly)

Aggregatzustand: Solid

pka: 14.65±0.40(Predicted)

Farbe: Off-White

InChI: InChI=1S/C15H20O3/c1-8-4-5-11-9(2)14(16)18-13(11)12-10(8)6-7-15(12,3)17/h11-13,17H,2,4-7H2,1,3H3/t11-,12-,13-,15+/m0/s1

InChIKey: RDJAFOWISVMOJY-PWNZVWSESA-N

SMILES: O1C(=O)C(=C)[C@]2([H])CCC(C)=C3[C@@]([H])([C@@]12[H])[C@@](O)(C)CC3

Sicherheit

Risiko- und Sicherheitserkl?rung
Gefahreninformationscode (GHS)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	P-Code
H302	Gesundheitssch?dlich bei Verschlucken.	Akute Toxizit?t oral	Kategorie 4	Warnung	P264, P270, P301+P312, P330, P501
H312	Gesundheitssch?dlich bei Hautkontakt.	Akute Toxizit?t dermal	Kategorie 4	Warnung	P280,P302+P352, P312, P322, P363,P501
H315	Verursacht Hautreizungen.	Hautreizung	Kategorie 2	Warnung	P264, P280, P302+P352, P321,P332+P313, P362
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	P264, P280, P305+P351+P338,P337+P313P

Sicherheit

P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Micheliolide Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Micheliolide, a sesquiterpene lactone is used in the inhibition of resistant acute leukemic cells. Selectively targets cancer stem and progenitor cells.

Source

Micheliolide (MCL) is a potentially stable sesquiterpene lactone, which can be isolated from Magnolia grandiflora L., Michelia champaca L., and Michelia compressa (Maxim.) Sarg. MCL and its Michael adduct dimethylaminomicheliolide (DMAMCL) display significant cytotoxicity against tumours. MCL is known to be firstly isolated by Ogura, Cordell from Michelia compressa (Maxim.) Sarg. as a cytotoxic active component. MCL is also a main biologically active constituent of Michelia champaca L., Magnolia grandiflora L., and Tanacetum parthenium Sch. Bip., Anthemis scrobicularis Yavin, and Michelia compressa (Maxim.) Sarg[1].
(3aS)-3aβ,4,5,7,8,9,9aβ,9bα-Octahydro-9β-hydroxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2(3H)-one

(3aS)-3aβ,4,5,7,8,9,9aβ,9bα-Octahydro-9β-hydroxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2(3H)-one

Micheliolide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Micheliolide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 126)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Accendatech Co., Ltd.	+8613132578992	yunhao.liu@accendatech.com	China	251	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253; +8618283602253	jancyzheng@gcgreenpure.com	China	954	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	4616	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58

68370-47-8()Verwandte Suche:

Cevadin Hyoscyamin 4,9-Epoxycevan-3β,4α,12,14,16β,17,20-heptol-3-veratrumat

(3aS)-3aβ,4,5,7,8,9,9aβ,9bα-Octahydro-9β-hydroxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2(3H)-one
Micheliolide
[3aS-(3aalpha,9alpha,9aalpha,9bbeta)]-3a,4,5,7,8,9,9a,9b-Octahydro-9-hydroxy-6,9-dimethyl-3-methylene-azuleno[4,5-b]furan-2(3H)-one
Micheliolide, BR
CS-1321
Micheliolide 68370-47-8
Mecheliolide
Azuleno[4,5-b]furan-2(3H)-one, 3a,4,5,7,8,9,9a,9b-octahydro-9-hydroxy-6,9-dimethyl-3-methylene-, (3aS,9R,9aS,9bS)-
(3aS,9R,9aS,9bS)-9-hydroxy-6,9-dimethyl-3-methylidene-4,5,7,8,9a,9b-hexahydro-3aH-azuleno[4,5-b]furan-2-one
Nuclear factor-κB,NF-κB,inhibit,Micheliolide,Nuclear factor-kappaB,Inhibitor
Micheliolide, 10 mM in DMSO
68370-47-8

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