Artemether
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- CAS-Nr.
- 71963-77-4
- Englisch Name:
- Artemether
- Synonyma:
- ARTHEMETER;artMether;Artimether;ArteMether (SM-224);[3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin;SM-224;Gvither;ArteMos;ArtenaM;Falcidol
- CBNumber:
- CB4248286
- Summenformel:
- C16H26O5
- Molgewicht:
- 298.37
- MOL-Datei:
- 71963-77-4.mol
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Artemether Eigenschaften
- Schmelzpunkt:
- 86-88°C
- alpha
- D19.5 +171° (c = 2.59 in CHCl3)
- Siedepunkt:
- 359.79°C (rough estimate)
- Dichte
- 1.0733 (rough estimate)
- Brechungsindex
- 1.6200 (estimate)
- storage temp.
- room temp
- L?slichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- powder
- Farbe
- off-white to light brown
- Optische Rotation
- [α]/D +155 to +175°, c = 0.5 in methanol
- Merck
- 14,815
- InChI
- InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
- InChIKey
- SXYIRMFQILZOAM-HVNFFKDJSA-N
- SMILES
- O1[C@]23[C@@]4([H])O[C@@](C)(CC[C@@]2([H])[C@H](C)CC[C@@]3([H])[C@@H](C)[C@@H](OC)O4)O1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
KD4165000 |
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| HS Code |
29329930 |
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| Speicherklasse |
5.2 - Organic peroxides and self-reacting hazardous materials |
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| Hazard Classifications |
Acute Tox. 4 Oral
Org. Perox. D |
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| Giftige Stoffe Daten |
71963-77-4(Hazardous Substances Data) |
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| Toxizit?t |
LD50 i.m. in mice: 263 mg/kg (China Cooperative Research Group on Qinghaosu) |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H242 |
Erw?rmung kann Brand verursachen. |
Organische Peroxide |
Typen C & D |
Achtung
Warnung |
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P210, P220, P234, P280, P370+P378,P403+P235, P411, P420, P501 |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P235 |
Kühl halten |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P370+P378 |
Bei Brand: zum L?schen verwenden. |
| P410 |
Vor Sonnenbestrahlung schützen. |
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Artemether Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Artemether is an antiparasitic compound and a derivative of artemisinin . It induces mortality in adult wild-type and
pfatp6-mutant
P. falciparum but the efficacy is decreased in the mutants (IC
50s = 8.2 and 13.5 nM, respectively). Artemether reduces parasitemia in
P. falciparum-infected monkeys and
P. berghei-infected mice with 50% curative dose (CD
50) values of 7.1 and 55 mg/kg, respectively. It also reduces the worm burden of
S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg. Formulations containing artemether have been used in the treatment of malaria.
Chemische Eigenschaften
White Solid
Verwenden
Artemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when
Definition
ChEBI: An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falcip
rum malaria.
Allgemeine Beschreibung
Artemisinin (ART) is a natural compound present in
Artemisia annua, a traditional Chinese plant.
Sicherheitsprofil
Poison by intramuscular route.Experimental reproductive effects. When heated todecomposition it emits acrid smoke and irritating fumes.
Artemether Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Artemether Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 678)Lieferanten
71963-77-4()Verwandte Suche:
- methyl-dihydroartemisinine
- ARTEMETHER
- ArtemetherC16H26O5
- cgp56696
- dihydroartemisininmethylether
- dihydroquinghaosumethylether
- Artesaph
- Artesian
- Decahydro-10-Methoxy-3,6,9-triMethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
- Falcidol
- Gvither
- Larither
- MalarteM
- ARTEMTHER
- Artemether
[3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
- ARTEMETHER PH. INT
- 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3-alpha,5a-beta,6-beta,8a-beta,9-alpha,12-beta,12aR)-, (+)
- (3R,5aα,8aα,12aR)-Decahydro-10β-methoxy-3,6α,9β-trimethyl-3,12α-epoxypyrano[4,3-j]-1,2-benzodioxepin
- (3R,5aα,8aα,12aR)-Decahydro-10β-methoxy-3,6α,9β-trimethyl-3β,12α-epoxypyrano[4,3-j]-1,2-benzodioxepin
- Dihydroartemisin methyl ether
- SM-224
- WR-254986
- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
- dihydroqinghaosu methyl ether
- Artemether (100 mg)
- ArteMos
- ArtenaM
- 3,12-epoxy-12h-pyrano(4,3-j)-1,2-benzodioxepin,decahydro-10-methoxy-3,6,9-trim
- 5a-beta,6-beta,8a-beta,9-alpha,12-beta,12ar)-(3-alph(+)-ethyl
- artemisininelactolmethylether
- Artemether>
- 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-
- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-Methoxy-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
- Artemether CP2015
- α-(N-Methyl-Benzylamino）-3-Hydroxyacetophenone Hydrochloride
- (3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromene
- Artemether USP/EP/BP
- Artemetherr
- ArtemetherQ: What is
Artemether Q: What is the CAS Number of
Artemether Q: What is the storage condition of
Artemether Q: What are the applications of
Artemether
- Artemether (1042780)
- Artemether 71963-77-4
- artMether
- ArteMether (SM-224)
- Artimether
- 13C,2H3]-β-Artemether
- Artemether, ≥ 98.0%
- (+)-Artemether
- Artemether, 10 mM in DMSO
- Alpha-artemether RS
- Artemether RS
- (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane
- [3r-(3r,5as,6s,8as,9r,10r,12s,12ar**)]-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin
- ARTHEMETER
- Artemether (Standard)
- 71963-77-4
- 963-77-4
- C16H26O5
- Chiral Reagents
