BI-9564
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- CAS-Nr.
- 1883429-22-8
- Englisch Name:
- BI-9564
- Synonyma:
- CS-2421;BI-9564;BI-9564 ，S8113;BI-9564 (BI 9564;BI-9564 >=97% (HPLC);BI-9564, 10 mM in DMSO;BI-9564,Inhibitor,Epigenetic Reader Domain,inhibit;4-(4-((Dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one;2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-;4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
- CBNumber:
- CB43134322
- Summenformel:
- C20H23N3O3
- Molgewicht:
- 353.41
- MOL-Datei:
- 1883429-22-8.mol
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BI-9564 Eigenschaften
- storage temp.
- Store at -20°C
- L?slichkeit
- ≥8.82 mg/mL in DMSO with ultrasonic,≥8.32 mg/mL in EtOH with ultrasonic,insoluble in H2O
- Aggregatzustand
- crystalline solid
- Farbe
- White to off-white
- InChI
- InChI=1S/C20H23N3O3/c1-22(2)11-13-8-19(26-5)15(9-18(13)25-4)17-12-23(3)20(24)16-10-21-7-6-14(16)17/h6-10,12H,11H2,1-5H3
- InChIKey
- BJFSUDWKXGMUKA-UHFFFAOYSA-N
- SMILES
- C1(=O)C2C(=CC=NC=2)C(C2=CC(OC)=C(CN(C)C)C=C2OC)=CN1C
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
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BI-9564 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (K
ds = 14.1 and 239 nM; IC
50s = 75 nM and 3.4 μM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 μM and 1 μM, respectively. It does not bind to other bromodomain-containing BET family members (IC
50s >100 μM as assessed by AlphaScreen), kinases, or G protein-coupled receptors and shows off-target selectivity only to the CECR2 bromodomain in
in vitro ITC assays (K
d = 258 nM), but not in cell-based assays at concentrations up to 1 μM. BI-9564 has been shown to inhibit the growth of EOL-1 AML cells both
in vitro (EC
50 = 800 nM) and in a disseminated mouse model of AML (180 mg/kg/day). See the
Structural Genomics Consortium (SGC) website for more information.
BI-9564 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
BI-9564 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 87)Lieferanten
1883429-22-8()Verwandte Suche:
- BI-9564
- 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
- BI-9564 (BI 9564
- CS-2421
- 2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-
- BI-9564 >=97% (HPLC)
- BI-9564,Inhibitor,Epigenetic Reader Domain,inhibit
- 4-(4-((Dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one
- BI-9564, 10 mM in DMSO
- BI-9564 ，S8113
- 1883429-22-8
