2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン
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- CAS番號.
- 1883429-22-8
- 化學(xué)名:
- 2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン
- 別名:
- 4-{4-[(ジメチルアミノ)メチル]-2,5-ジメトキシフェニル}-2-メチル-1,2-ジヒドロ-2,7-ナフチリジン-1-オン;2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン
- 英語名:
- BI-9564
- 英語別名:
- CS-2421;BI-9564;BI-9564 ，S8113;BI-9564 (BI 9564;BI-9564 >=97% (HPLC);BI-9564, 10 mM in DMSO;BI-9564,Inhibitor,Epigenetic Reader Domain,inhibit;4-(4-((Dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one;2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-;4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
- CBNumber:
- CB43134322
- 化學(xué)式:
- C20H23N3O3
- 分子量:
- 353.41
- MOL File:
- 1883429-22-8.mol
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2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン 物理性質(zhì)
- 貯蔵溫度 :
- Store at -20°C
- 溶解性:
- ≥8.82 mg/mL in DMSO with ultrasonic,≥8.32 mg/mL in EtOH with ultrasonic,insoluble in H2O
- 外見 :
- crystalline solid
- 色:
- White to off-white
- InChI:
- InChI=1S/C20H23N3O3/c1-22(2)11-13-8-19(26-5)15(9-18(13)25-4)17-12-23(3)20(24)16-10-21-7-6-14(16)17/h6-10,12H,11H2,1-5H3
- InChIKey:
- BJFSUDWKXGMUKA-UHFFFAOYSA-N
- SMILES:
- C1(=O)C2C(=CC=NC=2)C(C2=CC(OC)=C(CN(C)C)C=C2OC)=CN1C
安全性情報(bào)
- リスクと安全性に関する聲明
- 危険有害性情報(bào)のコード(GHS)
| WGK Germany |
WGK 3 |
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| ストレージクラス |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Acute Tox. 3 Oral |
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| 絵表示（GHS） |
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| 注意喚起語 |
危険 |
| 危険有害性情報(bào) |
| コード |
危険有害性情報(bào) |
危険有害性クラス |
區(qū)分 |
注意喚起語 |
シンボル |
P コード |
| H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
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P264, P270, P301+P310, P321, P330,P405, P501 |
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| 注意書き |
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2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン 価格
もっと(2)
| メーカー |
製品番號 |
製品説明 |
CAS番號 |
包裝 |
価格 |
更新時(shí)間 |
購入 |
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富士フイルム和光純薬株式會(huì)社(wako)
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SML1655 |
BI-9564 ≥97% (HPLC)
≥97% (HPLC) |
1883429-22-8 |
5mg |
￥28500 |
2024-03-01 |
購入 |
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富士フイルム和光純薬株式會(huì)社(wako)
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SML1655 |
BI-9564 ≥97% (HPLC)
≥97% (HPLC) |
1883429-22-8 |
25mg |
￥114000 |
2024-03-01 |
購入 |
2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン 化學(xué)特性,用途語,生産方法
説明
BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (K
ds = 14.1 and 239 nM; IC
50s = 75 nM and 3.4 μM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 μM and 1 μM, respectively. It does not bind to other bromodomain-containing BET family members (IC
50s >100 μM as assessed by AlphaScreen), kinases, or G protein-coupled receptors and shows off-target selectivity only to the CECR2 bromodomain in
in vitro ITC assays (K
d = 258 nM), but not in cell-based assays at concentrations up to 1 μM. BI-9564 has been shown to inhibit the growth of EOL-1 AML cells both
in vitro (EC
50 = 800 nM) and in a disseminated mouse model of AML (180 mg/kg/day). See the
Structural Genomics Consortium (SGC) website for more information.
2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品
2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン 生産企業(yè)
Global( 86)Suppliers
2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン スペクトルデータ(1HNMR)
1883429-22-8(2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン)キーワード:
- 1883429-22-8
- BI-9564
- 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
- BI-9564 (BI 9564
- CS-2421
- 2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-
- BI-9564 >=97% (HPLC)
- BI-9564,Inhibitor,Epigenetic Reader Domain,inhibit
- 4-(4-((Dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one
- BI-9564, 10 mM in DMSO
- BI-9564 ，S8113
- 4-{4-[(ジメチルアミノ)メチル]-2,5-ジメトキシフェニル}-2-メチル-1,2-ジヒドロ-2,7-ナフチリジン-1-オン
- 2-メチル-4-[2,5-ジメトキシ-4-[(ジメチルアミノ)メチル]フェニル]-2,7-ナフチリジン-1(2H)-オン