PROADIFEN HYDROCHLORIDE
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- CAS-Nr.
- 62-68-0
- Englisch Name:
- PROADIFEN HYDROCHLORIDE
- Synonyma:
- skf525a;PROADIFEN;SKF-525A, HYDROCHLORIDE;5171rp;U 5446;SKF 525;SU-5446;nsc39690;SKF-525A HCL;PROADIFEN, HCL
- CBNumber:
- CB5120727
- Summenformel:
- C23H32ClNO2
- Molgewicht:
- 389.96
- MOL-Datei:
- 62-68-0.mol
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PROADIFEN HYDROCHLORIDE Eigenschaften
- Schmelzpunkt:
- 122-123°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO (up to 20 mg/ml)
- Aggregatzustand
- White solid
- Farbe
- Lustrous crystals from Me2CO/pet ether
- Wasserl?slichkeit
- Soluble in methanol or water
- Stabilit?t:
- Store in Freezer
- Major Application
- forensics and toxicology
pharmaceutical (small molecule)
- InChI
- 1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H
- InChIKey
- FHIKZROVIDCMJA-UHFFFAOYSA-N
- SMILES
- Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2
- EPA chemische Informationen
- Proadifen hydrochloride (62-68-0)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| S-S?tze: |
36-24/25 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
YV7175000 |
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| HS Code |
29221990 |
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| Speicherklasse |
11 - Combustible Solids |
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| Toxizit?t |
LD50 oral in rat: 2140mg/kg |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P330 |
Mund ausspülen. |
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PROADIFEN HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
S-S?tze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
SKF 525A is a widely used, nonspecific cytochrome P (CYP)450 inhibitor that demonstrates 100% inhibition of the various CYP450 isoforms at 1-
100 μM. It therefore potentiates the effects of many different drugs by inhibiting their metabolism (IC
50 values in the μM range when tested using human liver microsomes). SKF 525A inhibits CYP450-
dependent arachidonic acid conversion to active EET metabolites, antagonizing the recovery of functional calcium pools. It also acts as a noncompetitive inhibitor of acetylcholine nicotinic receptors (IC
50 = 19 μM in mouse skeletal muscle).
Chemische Eigenschaften
Off-White Crystalline Solid
Verwenden
Proadifen hydrochloride is an inhibitor of NOS1, AChR, cytochrome P-450, and KIR6. Proadifen hydrochloride bind to the protein moiety of P-450, also reduced the hypoxic response. of Proadifen hydrochloride have good antiarrhythmic effects. SKF-525A substantially reduced the depletion of cardiac norepinephrine.
Sicherheitsprofil
Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl.
PROADIFEN HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PROADIFEN HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 139)Lieferanten
62-68-0()Verwandte Suche:
- SKF-525A HYDROCHLORIDE >98% (PROADIFEN)
- ALPHA-PHENYL-ALPHA-PROPYLBENZENEACETIC ACID 2-[DIETHYLAMINO]ETHYL ESTER, HCL
- ALPHA-PHENYL-ALPHA-PROPYLBENZENEACETIC ACID 2-[DIETHYLAMINO]ETHYL ESTER HYDROCHLORIDE
- SK AND F 525A HYDROCHLORIDE
- SKF-525A HCL
- 2’-diethylaminoethyl2,2-diphenylpentanoatehydrochloride
- 2-diethylaminoethyl2,2-diphenylvaleratehydrochloride
- 2-diethylaminoethylalpha,alpha-diphenylvaleratehydrochloride
- 5171rp
- alpha-phenyl-alpha-propyl-benzeneaceticaci2-(diethylamino)ethylesterh
- beta-diethylaminoethyldiphenylpropylacetatehydrochloride
- α-phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester
- Proadifen, HCl, α-Phenyl-α-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl
- N,N-Diethylaminoethyl 2,2-diphenylvalerate, SKF-525A, α-Phenyl-α-propylbenzeneacetic acid 2-(diethylamino)ethyl ester
- N,N-Diethylaminoethyl 2,2-diphenylvalerate
- SKF 525
- U 5446
- 2-(diethylamino)ethyl ester
- ACETICACID,PROPYLDIPHENYL-,2-(DIETHYLAMINO)ETHYLESTER
- PROADIFEN HYDROCHLORIDE
- PROADIFEN, HCL
- Benzeneacetic acid, .alpha.-phenyl-.alpha.-propyl-, 2-(diethylamino)ethyl ester, hydrochloride
- Proadifen, HCl, a-Phenyl-a-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl
- valericacid,2,2-diphenyl-,2-(diethylamino)ethylester,hydrochloride
- propyladiphenin
- pentanoicacid,2,2-diphenyl-,2-(n,n-diethylamino)ethylester,hydrochloride
- nsc39690
- diethylaminoethanolesterofdiphenylpropylaceticacidhydrochloride
- SKF-525A, Hydrochloride - CAS 62-68-0 - Calbiochem
- SU-5446
- SKF-525A, HYDROCHLORIDE
- Proadifen hydrochloride (SKF-525A), Cytochrome P450 inhibitor
- 2,2-diphenylpentanoic acid2,2-diethylaminoethyl esterhydrochloride
- PROADIFEN
- skf525a
- 62-68-0
- 1302-33-0
- C23H32ClNO2
- C32H31NO2HCl
- C23H31NO2HCl
- Biochemicals and Reagents
- BioChemical
- L to O
- Enzymes, Inhibitors, and Substrates
- Enzyme Inhibitors
- Enzyme Inhibitors by Enzyme
- Nitric Oxide Synthase neuronal
- Inhibitors
- All Inhibitors
- Amines
- Aromatics
- CLORINE
