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PROADIFEN HYDROCHLORIDE

PROADIFEN HYDROCHLORIDE ??? ???
?? ??:
62-68-0
???:
PROADIFEN HYDROCHLORIDE
???(??):
skf525a;PROADIFEN;SKF-525A, HYDROCHLORIDE;5171rp;U 5446;SKF 525;SU-5446;nsc39690;SKF-525A HCL;PROADIFEN, HCL
CBNumber:
CB5120727
???:
C23H32ClNO2
??? ??:
389.96
MOL ??:
62-68-0.mol
MSDS ??:
SDS

PROADIFEN HYDROCHLORIDE ??

???
122-123°C
?? ??
Inert atmosphere,Store in freezer, under -20°C
???
DMSO? ???(?? 20mg/ml)
??? ??
?? ??
??
Me2CO/?? ????? ???
???
??? ?? ?? ???
???
???? ??
?? ??
??? ? ???
???(???)
InChI
1S/C23H31NO2.ClH/c1-4-17-23(20-13-9-7-10-14-20,21-15-11-8-12-16-21)22(25)26-19-18-24(5-2)6-3;/h7-16H,4-6,17-19H2,1-3H3;1H
InChIKey
FHIKZROVIDCMJA-UHFFFAOYSA-N
SMILES
Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2
EPA
Proadifen hydrochloride (62-68-0)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 22
????? 36-24/25
WGK ?? 3
RTECS ?? YV7175000
HS ?? 29221990
???? ??? 11 - Combustible Solids
?? LD50 oral in rat: 2140mg/kg
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? P264, P270, P301+P312, P330, P501
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P330 ?? ?????.
NFPA 704
0
2 0

PROADIFEN HYDROCHLORIDE C??? ??, ??, ??

??

SKF 525A is a widely used, nonspecific cytochrome P (CYP)450 inhibitor that demonstrates 100% inhibition of the various CYP450 isoforms at 1-100 μM. It therefore potentiates the effects of many different drugs by inhibiting their metabolism (IC50 values in the μM range when tested using human liver microsomes). SKF 525A inhibits CYP450-dependent arachidonic acid conversion to active EET metabolites, antagonizing the recovery of functional calcium pools. It also acts as a noncompetitive inhibitor of acetylcholine nicotinic receptors (IC50 = 19 μM in mouse skeletal muscle).

??? ??

Off-White Crystalline Solid

??

Proadifen hydrochloride is an inhibitor of NOS1, AChR, cytochrome P-450, and KIR6. Proadifen hydrochloride bind to the protein moiety of P-450, also reduced the hypoxic response. of Proadifen hydrochloride have good antiarrhythmic effects. SKF-525A substantially reduced the depletion of cardiac norepinephrine.

Safety Profile

Poison by intraperitoneal, subcutaneous, and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and HCl.

PROADIFEN HYDROCHLORIDE ?? ?? ? ???

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?? ??


PROADIFEN HYDROCHLORIDE ?? ??

???( 141)?? ??
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PROADIFEN HYDROCHLORIDE ?? ??:

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