Idarubicin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.
R61:Kann das Kind im Mutterleib sch?digen.
R28:Sehr giftig beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Verwenden
Antineoplastic.
Indications
Idarubicin (Idamycin) differs from its parent compound,
daunorubicin, by the absence of the methoxy
group in the anthracycline ring structure. Its mechanisms
of action and resistance are similar to those of
doxorubicin and daunorubicin; however, it is more
lipophilic and more potent than these other anthracyclines.
Idarubicin undergoes extensive hepatic metabolism
and biliary excretion. Adverse reactions of idarubicin
are similar to those of its congeners.
Mechanism of action
Idarubicin is an anthracycline antitumor drug. It mainly exerts its therapeutic effect on acute leukemia by binding to DNA and inhibiting the activity of topoisomerase II, thereby disrupting DNA replication and transcription and causing DNA damage and cell death.
Idarubicin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
