Allopregnanolone

516-54-1

CAS-Nr.: 516-54-1

Englisch Name:: Allopregnanolone

Synonyma:: Brexanolone;Anlotinib Dihydrochloride;(3a)-Allopregnanolone;3α-hydroxy-5α-pregnan-20-one;1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one;(3alpha)-Allopregnanolone;allotetrahydroprogesterone;3α-hydroxy-5α-pregnan-20-one;Allopregnanolone(Brexanolone);5α-P

CBNumber:: CB5418550

Summenformel:: C21H34O2

Molgewicht:: 318.49

MOL-Datei:: 516-54-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 230

Allopregnanolone Eigenschaften

Schmelzpunkt:: 176-178°

alpha: D +87.7° (abs alc)

Siedepunkt:: 431.2±18.0 °C(Predicted)

Dichte: 1.053±0.06 g/cm3(Predicted)

storage temp.: Store at RT

L?slichkeit: chloroform: 20 mg/mL, clear, colorless

pka: 15.12±0.70(Predicted)

Aggregatzustand: White solid

Farbe: white

Merck: 13,272

BRN: 3211363

Stabilit?t:: Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

InChI: InChI=1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/s3

InChIKey: AURFZBICLPNKBZ-SYBPFIFISA-N

SMILES: [C@]12([H])CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CC[C@@]1([H])C[C@H](O)CC[C@]21C)C(=O)C |&1:0,4,6,9,11,15,18,22,r|

CAS Datenbank: 516-54-1(CAS DataBase Reference)

Sicherheit

S-S?tze:	22-24/25
WGK Germany	3
RTECS-Nr.	TU4383000
F	10

Allopregnanolone Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone . It acts as a positive allosteric modulator of GABA_A receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing δ subunits) and of GABA_C receptors at μM concentrations. Allopregnanolone displays effects similar to other GABA_A receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.

Verwenden

(3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain.

Biologische Aktivit?t

GABA A receptor positive allosteric modulator. Neuroactive steroid.

Synthese

synthesis of Brexanolone
Brexanolone synthesis

Allopregnanolone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Allopregnanolone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 230)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Jinan Million Pharmaceutical Co., Ltd	0531-68659554 +8613031714605	info@millionpharm.com	China	184	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
shandong perfect biotechnology co.ltd	+86-53169958659 +86-13153181156	sales@sdperfect.com	China	294	58
Hebei Xinsheng New Material Technology Co., LTD.	+86-16632316109	xinshengkeji@xsmaterial.com	China	1085	58
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +8617709210191	Jerry@xhobio.com	China	906	58
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Chenghui-Shuangda Chemical Co.,Ltd	+86-531-58897082	ericqiao@jnchsd.com	CHINA	158	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58

516-54-1()Verwandte Suche:

Alfadolon 3α,21-Dihydroxy-5α-pregnan-20-on 3-β-Hydroxy-5-α-pregnan-20-on 3α,21-Dihydroxy-5α-pregnan-11,20-dion-21-acetat 3α,17,21-Trihydroxy-5α-pregnan-20-on 3α,17-Dihydroxy-5α-pregnan-20-on 3-α,11-β,17-α,21-Tetrahydroxy-5-α-pregnan-20-on 3α,17,21-Trihydroxy-5α-pregnan-11,20-dion 3α,11β,21-Trihydroxy-5α-pregnan-20-on

1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
3-A-5-A-TETRAHYDROPROGESTERONE
3-alpha,5-alpha-pregnanolone
3α-OH-DHP
Allopregnan-3a-ol-20-one
(3α)-Allopregnanolone
3α,5α-Tetrahydroprogesterone
3α,5α-THP
3α-Hydroxy-5α-dihydroprogesterone
3α-Hydroxy-5α-pregnane-20-one
5α-P
3-alpha,5-alpha-tetrahydroprogesterone
3-alpha-hydroxy-5-alpha-pregnan-20-on
5alpha-Pregnan-20-one, 3alpha-hydroxy-
Pregnan-20-one, 3-hydroxy-, (3alpha,5alpha)-
5ALPHA-PREGNAN-3ALPHA-OL-20-ONE
3ALPHA-HYDROXY-5ALPHA-20-ONE
3ALPHA-HYDROXY-5ALPHA-PREGNAN-20-ONE
3ALPHA-OH-DHP
ALLOPREGNAN-3ALPHA-OL-20-ONE
1-[(3R,5S,8R,9S,10S,13R,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
5a-Pregnan-3alpha-ol-3-one
3α-Hydroxy-5α-pregnan-20-one, 3α-OH-DHP, Allopregnan-3α-ol-20-one
(3alpha,5alpha)-3-hydroxypregnan-20-one
Alpha - Pregnan - alpha - 3 ol - twenty - one, Brexanolone
5α-Pregnan-3α-ol-20-one
(3α,5β)-3-Hydroxy-pregnan-20-one
Allopregnan-3α-ol-20-one
1-[(3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10
5alpha progesterone 3alpha alcohol 20 one (tetrahydro progesterone)
Allopregnan-3 alpha-ol-20-one，Allopregnanolone
LJPC-0712
3Α;5Α-THP; SAGE547; SAGE 547; SAGE-547
3A-HYDROXY-5A-PREGNAN-20-ONE
Allopregnanolone - CAS 516-54-1 - Calbiochem
Brexanolone（SAGE-547）
1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-Hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
5alpha-Pregnan-3alpha-ol-20-one,3α-hydroxy-5α-pregnan-20-one
5alpha-Pregnan-3a-ol-20-one
Allopregnanolone (Solution)
5alpha-Pregnan-3alpha-ol-20-one,Brexanolone
allotetrahydroprogesterone
3α-Hydroxy-AlloProgesterone
Brexanolone/Allopregnan-3alpha-ol-20-one
Allopregnalone
Pregnan-20-one, 3-hydroxy-, (3α,5α)-
ALLOPREGNANOLONE
ASN16541
1-(3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethanone
5α-Pregnane-3α-ol-20-one
Allopregnanolone (exempt preparation)
Don't use progesterone
Pregnan-20-one,3-hydroxy-, (3a,5a)-
1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one
(3a)-Allopregnanolone
(3alpha)-Allopregnanolone
3α-hydroxy-5α-pregnan-20-one
3α-hydroxy-5α-pregnan-20-one

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