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Icatibant Acetate

Icatibant Acetate Struktur
138614-30-9
CAS-Nr.
138614-30-9
Englisch Name:
Icatibant Acetate
Synonyma:
CS-1399;Firazyr;HOE 140 Acetate;Arteband Acetate;lcatibant Acetate;Aldeibant acetate;Etibatide acetate;Icatibant Acetate;HOE-140 (Icatibant);Etiban acetate salt
CBNumber:
CB5497052
Summenformel:
C59H89N19O13S.C2H4O2
Molgewicht:
1364.59
MOL-Datei:
138614-30-9.mol

Icatibant Acetate Eigenschaften

storage temp. 
-20°C
L?slichkeit
DMSO:65.0(Max Conc. mg/mL);47.63(Max Conc. mM)
Ethanol:0.25(Max Conc. mg/mL);0.18(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);7.33(Max Conc. mM)
Aggregatzustand
A crystalline solid
Farbe
White to off-white
InChIKey
HKMZRZUEADSZDQ-SUJPMXFINA-N

Sicherheit

WGK Germany  3
Speicherklasse 11 - Combustible Solids

Icatibant Acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a Ki of 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE.

Verwenden

Antagonist (bradykinin).

Definition

ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.

Icatibant Acetate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Icatibant Acetate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 165)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Shengnuo Biopharm Co.,Ltd
+8613880038419
leili@snbiopharm.com China 70 58
RongNa Biotechnology Co.,Ltd
+86-86-13583358881 +8618560316533
Brad@rongnabiotech.com China 3378 58
Hebei Xinsheng New Material Technology Co., LTD.
+86-16632316109
xinshengkeji@xsmaterial.com China 1085 58
Nantong Guangyuan Chemicl Co,Ltd
+undefined17712220823
admin@guyunchem.com China 615 58
Hefei Lbao Physical & Chemical Science Co.,Ltd
+15184799099
lbaochemicals@gmail.com China 670 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29812 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58
Hebei Yanxi Chemical Co., Ltd.
+8618531123677
faithe@yan-xi.com China 5853 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354
marketing@targetmol.com United States 32467 58

138614-30-9()Verwandte Suche:


  • Firazyr
  • HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN
  • d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg
  • Icatibant acetate, D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg
  • HOE 140 Acetate
  • lcatibant Acetate
  • HOE-140 (Icatibant)
  • HOE140; ICATIBANT;HOE 140
  • CS-1399
  • (2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxy-pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-yl-propanoyl]amino]-3-hydroxy-propanoyl]3,4-dihydro-1H-isoquinoline-3-carbonyl]2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
  • colitis,Bradykinin Receptor,inhibit,angiotensin,Icatibant Acetate,HOE140,ulcerative,Icatibant,HOE-140,Inhibitor,HOE 140
  • Aldeibant acetate
  • H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-DL-Tic-Oic-Arg-OH.CH3CO2H
  • Icatibant Acetate, 10 mM in DMSO
  • Etiban acetate salt
  • Etibatide acetate
  • Icatibant Acetate
  • Arteband Acetate
  • 138614-30-9
  • C59H89N19O13SxC2H4O2
  • C59H89N19O13S
  • C59H90N20O12SC2H4O2n
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