(R)-N-Boc-glutamic acid-1,5-dimethyl ester
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- CAS-Nr.
- 59279-60-6
- Englisch Name:
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester
- Synonyma:
- N-Boc-L-Glutamic acid dimethyl ester;BOC-GLU(OME)-OME;BOC-L-GLU(OME)-OME;Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate;BOC-GLU(OME)-OME 45G;BOC-L-GLUTAMIC ACID DIMETHYL ESTER;dimethyl(tert-butoxycarbonyl)-L-glutamate;(S)-diMethyl 2-(tert-butoxycarbonylaMino)pentanedioate;Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate;BOC-L-GLU(ME)-OME
- CBNumber:
- CB5853917
- Summenformel:
- C12H21NO6
- Molgewicht:
- 275.3
- MOL-Datei:
- 59279-60-6.mol
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(R)-N-Boc-glutamic acid-1,5-dimethyl ester Eigenschaften
- Schmelzpunkt:
- 43.0 to 47.0 °C
- Siedepunkt:
- 370.9±32.0 °C(Predicted)
- Dichte
- 1.117±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly)
- pka
- 10.86±0.46(Predicted)
- Aggregatzustand
- Liquid
- Farbe
- Colorless to pale yellow
- Optische Rotation
- Consistent with structure
- InChI
- InChI=1S/C12H21NO6/c1-12(2,3)19-11(16)13-8(10(15)18-5)6-7-9(14)17-4/h8H,6-7H2,1-5H3,(H,13,16)/t8-/m0/s1
- InChIKey
- QNSPKWUAZQIIGZ-QMMMGPOBSA-N
- SMILES
- C(OC)(=O)[C@H](CCC(OC)=O)NC(OC(C)(C)C)=O
- CAS Datenbank
- 59279-60-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
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P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(R)-N-Boc-glutamic acid-1,5-dimethyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(R)-N-Boc-glutamic acid-1,5-dimethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.
Synthese
L-glutamic acid (10.0 g, 67.97 mmol) was dissolved in 200 mL of methanol, and SOCl2(10.85 mL, 149.53 mmol)was slowly added dropwise under an ice bath. After the addition, reflux was performed at 65 C. After 2 hours, the reaction system was cooled to room temperature, and methanol was evaporated to dryness under reduced pressure to obtain a colorless viscous substance.This colorless viscous substance was dissolved in 200 mL of THF, (Boc)2O (22.25 g, 101.95 mmol) was addedunder an ice bath, and triethylamine (14.13 mL, 101.95 mmol) was slowly added dropwise.After the addition was complete, the reaction was allowed to proceed at room temperature overnight.After completion of the reaction, the solvent was distilled off under reduced pressure.The residue was dissolved in 200 mL of dichloromethane.The organic phase was washed with water (200 mL * 2), saturated citric acid solution (200 mL * 2), saturated sodium bicarbonate solution (200 mL * 2), and saturated brine (200 mL * 2) in that order.The organic phase was dried over anhydrous Na2SO4. Thefiltrate was collected by filtration, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 4: 1 v / v) to give a colorless oily product (R)-N-Boc-glutamic acid-1,5-dimethyl ester (18.34 g, yield 98%)
(R)-N-Boc-glutamic acid-1,5-dimethyl ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(R)-N-Boc-glutamic acid-1,5-dimethyl ester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 315)Lieferanten
59279-60-6()Verwandte Suche:
- Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
- N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GLUTAMIC ACID DI-METHYL DIESTER
- N-ALPHA-T-BUTYLOXYCARBONYL-L-GLUTAMIC ACID DIMETHYL DIESTER
- N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID ALPHA, GAMMA-DIMETHYL ESTER
- (R)-N-BOC-GLUTAMIC ACID-1,5-DIMETHYL ESTER
- (S)-2-tert-ButoxycarbonylaMinopentanedioic acid diMethyl ester
- N-alpha-t-Butyloxycarbonyl-L-glutamic acid di-methyl ester
- Dimethyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate
- N-Boc-L-GlutaMic Acid diMethyl ester/(S)-2-tert-ButoxycarbonylaMino-pentanedioic acid diMethyl ester
(S)-2-tert-ButoxycarbonylaMino-pentanedioic acid diMethyl ester
- N-Boc-L-glutaMic acid 1,5-diMethyl ester, 97%
- N-α-(t-Butoxycarbonyl)-L-glutamic acid α,γ-dimethyl ester
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester （PF-07321332 Paxlovid intermediate）
- Dimethyl Boc-Glutamate
- 59279-60-6---(R)-N-Boc-glutamic acid-1,5-dimethyl ester
- 1,5-dimethyl (2S)-2-{[(tert-butoxy)carbonyl]amino}pentanedioate
- (R)-N-Boc-glutamic acid-1，5-dinethyl ester
- (Tert-Butoxy)Carbonyl Glu(OMe)-OMe (Syrup)
- Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate >
- u(Ome)-OMe
- L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1,5-dimethyl ester
- imethyl(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate
- N-(tert-Butoxycarbonyl)-L-glutamic Acid Dimethyl Ester
- Dimethyl N-Boc-L-glutamate
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester USP/EP/BP
- Boc-Glu-OMe(OMe) USP/EP/BP
- BOC-L-GLU(OME)-OME
- BOC-L-GLUTAMIC ACID DIMETHYL ESTER
- BOC-GLU(OME)-OME 45G
- BOC-L-GLU(ME)-OME
- (S)-diMethyl 2-(tert-butoxycarbonylaMino)pentanedioate
- Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
- dimethyl(tert-butoxycarbonyl)-L-glutamate
- 1,5-Dimethyl N-[(1,1-dimethylethoxy)carbonyl]-L-glutamate
- N-Boc-L-glutamic acid 1,5-dimethyl
- Dimethyl (S)-(N-tert-butoxycarbonyl)glutamate
- (R)-N-Boc-glutamic acid-1,5-dimethyl este
- BOC-L-glutamate dimethyl ester
- Boc-L-Glu(Ome)-Ome-OH
- N-tert-butoxycarbonyl-L-dimethyl glutamate
- Dimethyl N-(tert-Butoxycarbonyl)-L<
- N-Boc-L-glutamic Acid 1,5-Dimethyl Ester
- 1,5-Dimethyl N-N-BOC-L-glutamate
- N-Boc-L-Glutamic acid dimethyl ester
- Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate
- BOC-GLU(OME)-OME
- 59279-60-6
- 59579-60-6
- 52979-60-6
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