Saracatinib
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- CAS-Nr.
- 379231-04-6
- Englisch Name:
- Saracatinib
- Synonyma:
- CS-69;Gemcabene Calcium;7-[2-[4-Methylpiperazin-1-yl]ethoxy]-5-[[tetrahydropyran-4-yl]oxy]-4-[[6-chloro-2,3-Methylenedioxyphenyl]aMino]quinazoline;AZ-0530;ADZ-0530;AZD-O530;EOS-61866;NSC-735464;saracatinib;AZ-10353926
- CBNumber:
- CB61518531
- Summenformel:
- C27H32ClN5O5
- Molgewicht:
- 542.03
- MOL-Datei:
- 379231-04-6.mol
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Saracatinib Eigenschaften
- Schmelzpunkt:
- 84-89°C
- Siedepunkt:
- 671.2±55.0 °C(Predicted)
- Dichte
- 1.348
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
- Aggregatzustand
- solid
- pka
- 7.55±0.10(Predicted)
- Farbe
- White
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- OUKYUETWWIPKQR-UHFFFAOYSA-N
- SMILES
- N1=C2C(C(OC3CCOCC3)=CC(OCCN3CCN(C)CC3)=C2)=C(NC2=C3C(=CC=C2Cl)OCO3)N=C1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Saracatinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Saracatinib is a dual inhibitor of the tyrosine kinases c-
Src and Abl (IC
50 = 2.7 and 30 nM, respectively). It less effectively inhibits other receptor and non-
receptor tyrosine kinases as well as assorted serine/threonine kinases. Saracatinib is orally available and blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival. Through its effects on c-
Src, it reduces osteoclast bone resorption. Saracatinib also blocks denque virus RNA replication through its effect on Fyn kinase.
Chemische Eigenschaften
White Solid
Saracatinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Saracatinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 221)Lieferanten
379231-04-6()Verwandte Suche:
- (S)-2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetaMide
- N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine Saracatinib (AZD0530)
- Saracatinib N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
- Saracatinib, >=98%
- saracatinib
- N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine
- 4-(6-Chloro-2,3-methylenedioxyanilino)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-tetrahydropyran-4-yloxyquinazoline
- 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methyl-1-piperazinyl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)-
- N-(5-Chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine
- N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine
- Saracatinib (AZD0530)
- AZD0530(Saracatinib)
- AZD0530 difuMarate
- N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyr
- AZD0530; AZD-0530; AZD 0530
- EOS-61866
- Saracatinib USP/EP/BP
- TIANFUCHEM-- Saracatinib
- Saracatinib AZD0530 AZD-0530
- N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine
- Saracatinib, 10 mM in DMSO
- ADZ-0530
- AZ-0530
- AZ-10353926
- AZD-O530
- NSC-735464
- AZD0530/379231-04-6/98%
- N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methyl-piperazin-1-yl)ethoxy)-5-((tetrahydro-2H-pyran-4-yloxy))-quinazolin-4-ylamine
- 7-[2-[4-Methylpiperazin-1-yl]ethoxy]-5-[[tetrahydropyran-4-yl]oxy]-4-[[6-chloro-2,3-Methylenedioxyphenyl]aMino]quinazoline
- CS-69
- Gemcabene Calcium
- 379231-04-6
- C27H32ClN5O5
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Protein Kinase Inhibitors and Activators
- APIs
- Inhibitors
