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ChemicalBook >> CAS DataBase List >>Saracatinib

Saracatinib

CAS No.
379231-04-6
Chemical Name:
Saracatinib
Synonyms
CS-69;Gemcabene Calcium;7-[2-[4-Methylpiperazin-1-yl]ethoxy]-5-[[tetrahydropyran-4-yl]oxy]-4-[[6-chloro-2,3-Methylenedioxyphenyl]aMino]quinazoline;AZ-0530;ADZ-0530;AZD-O530;EOS-61866;NSC-735464;saracatinib;AZ-10353926
CBNumber:
CB61518531
Molecular Formula:
C27H32ClN5O5
Molecular Weight:
542.03
MDL Number:
MFCD09832698
MOL File:
379231-04-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
AZD0530 ≥98% (HPLC) SML3195 5 mg $98.1
AZD0530 ≥98% (HPLC) SML3195 10 mg $395
Saracatinib A3611 25MG $118
Saracatinib ≥90% 11497 5mg $35
Saracatinib ≥90% 11497 10mg $59
More product size

Saracatinib Properties

Melting point 84-89°C
Boiling point 671.2±55.0 °C(Predicted)
Density 1.348
storage temp. -20°C
solubility Soluble in DMSO (50 mg/ml) and ethanol (54 mg/mL with warming)
form solid
pka 7.55±0.10(Predicted)
color White
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey OUKYUETWWIPKQR-UHFFFAOYSA-N
SMILES N1=C2C(C(OC3CCOCC3)=CC(OCCN3CCN(C)CC3)=C2)=C(NC2=C3C(=CC=C2Cl)OCO3)N=C1
FDA UNII 9KD24QGH76
NCI Drug Dictionary saracatinib
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H317-H319
Precautionary statements  P280-P305+P351+P338
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

Saracatinib price More Price(87)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3195 AZD0530 ≥98% (HPLC) 379231-04-6 5 mg $98.1 2026-04-30 Buy
Sigma-Aldrich SML3195 AZD0530 ≥98% (HPLC) 379231-04-6 10 mg $395 2026-04-30 Buy
TCI Chemical A3611 Saracatinib 379231-04-6 25MG $118 2026-04-30 Buy
Cayman Chemical 11497 Saracatinib ≥90% 379231-04-6 5mg $35 2026-04-30 Buy
Cayman Chemical 11497 Saracatinib ≥90% 379231-04-6 10mg $59 2026-04-30 Buy
Product number Packaging Price Buy
SML3195 5 mg $98.1 Buy
SML3195 10 mg $395 Buy
A3611 25MG $118 Buy
11497 5mg $35 Buy
11497 10mg $59 Buy

Saracatinib Chemical Properties,Uses,Production

Description

Saracatinib is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC50 = 2.7 and 30 nM, respectively). It less effectively inhibits other receptor and non-receptor tyrosine kinases as well as assorted serine/threonine kinases. Saracatinib is orally available and blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival. Through its effects on c-Src, it reduces osteoclast bone resorption. Saracatinib also blocks denque virus RNA replication through its effect on Fyn kinase.

Chemical Properties

White Solid

Uses

An oral, selective dual inhibitor of Src and ABL kinase. It is a COVID19-related research product.

Definition

ChEBI: Saracatinib is a member of the class of quinazolines that is quinazoline substituted by (5-chloro-2H-1,3-benzodioxol-4-yl)amino, (oxan-4-yl)oxy and 2-(4-methylpiperazin-1-yl)ethoxy groups at positions 4, 5 and 7, respectively. It is a dual inhibitor of the tyrosine kinases c-Src and Abl (IC50 = 2.7 and 30 nM, respectively). Saracatinib was originally developed by AstraZeneca for the treatment of cancer but in 2019 it was granted orphan drug designation by the US Food and Drug Administration for the treatment of idiopathic pulmonary fibrosis (IPF), a type of lung disease that results in scarring (fibrosis) of the lungs. It has a role as an antineoplastic agent, an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, a radiosensitizing agent, an autophagy inducer, an apoptosis inducer and an anticoronaviral agent. It is a member of quinazolines, a secondary amino compound, a N-methylpiperazine, an aromatic ether, a member of oxanes, a member of benzodioxoles, an organochlorine compound and a diether.

storage

Store at -20°C

References

[1] LAURENT F. HENNEQUIN. N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor?[J]. Journal of Medicinal Chemistry, 2006, 49 22: 6465-6488. DOI:10.1021/jm060434q
[2] TIM P. GREEN . Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530[J]. Molecular Oncology, 2009, 3 3: Pages 248-261. DOI:10.1016/j.molonc.2009.01.002
[3] MELISSANNE DE WISPELAERE  Priscilla L Y  Amy J LaCroix. The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase.[J]. Journal of Virology, 2013: 7367-7381. DOI:10.1128/jvi.00632-13
[4] JIN SOO SHIN. Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro.[J]. Viruses, 2018. DOI:10.3390/v10060283
[5] SI JIE TANG. Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.[J]. Acta Neuropathologica Communications, 2020: 96. DOI:10.1186/s40478-020-00976-9
[6] ADAM C. KAUFMAN BS, PHD  Stephen M S M, PHD. Fyn inhibition rescues established memory and synapse loss in Alzheimer mice[J]. Annals of Neurology, 2015, 77 6: 953-971. DOI:10.1002/ana.24394

Saracatinib Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 223)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32466 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29093 58
AFINE CHEMICALS LIMITED 		+86-571-85134551 +86-18958018566 info@afinechem.com China 15079 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58

View Lastest Price from Saracatinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Saracatinib pictures 2026-07-27 Saracatinib
379231-04-6
 $59.00-148.00 99.31% 10g TargetMol Chemicals Inc.
Saracatinib USP/EP/BP pictures 2025-11-18 Saracatinib USP/EP/BP
379231-04-6
 $1.10 1g 99.9% 100 Tons Min Dideu Industries Group Limited
Saracatinib pictures 2024-10-22 Saracatinib
379231-04-6
 $1.00 1g 85.0-99.8% 20ton Career Henan Chemica Co
  • Saracatinib pictures
  • Saracatinib
    379231-04-6
  • $59.00-148.00
  • 99.31%
  • TargetMol Chemicals Inc.
  • Saracatinib pictures
  • Saracatinib
    379231-04-6
  • $1.00
  • 85.0-99.8%
  • Career Henan Chemica Co

Saracatinib Spectrum

(S)-2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-hydroxyphenyl)acetaMide N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine Saracatinib (AZD0530) Saracatinib N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine Saracatinib, >=98% saracatinib N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine 4-(6-Chloro-2,3-methylenedioxyanilino)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-tetrahydropyran-4-yloxyquinazoline 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methyl-1-piperazinyl)ethoxy)-5-((tetrahydro-2H-pyran-4-yl)oxy)- N-(5-Chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine Saracatinib (AZD0530) AZD0530(Saracatinib) AZD0530 difuMarate N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyr AZD0530; AZD-0530; AZD 0530 EOS-61866 Saracatinib USP/EP/BP TIANFUCHEM-- Saracatinib Saracatinib AZD0530 AZD-0530 N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine Saracatinib, 10 mM in DMSO ADZ-0530 AZ-0530 AZ-10353926 AZD-O530 NSC-735464 AZD0530/379231-04-6/98% N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-(2-(4-methyl-piperazin-1-yl)ethoxy)-5-((tetrahydro-2H-pyran-4-yloxy))-quinazolin-4-ylamine 7-[2-[4-Methylpiperazin-1-yl]ethoxy]-5-[[tetrahydropyran-4-yl]oxy]-4-[[6-chloro-2,3-Methylenedioxyphenyl]aMino]quinazoline CS-69 Gemcabene Calcium 379231-04-6 C27H32ClN5O5 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators APIs Inhibitors
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