tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
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- CAS-Nr.
- 571188-59-5
- Englisch Name:
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- Synonyma:
- 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;OTAVA-BB 1207229;1-Boc-4-(6-amino-3-pyridyl)piperazine;4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic;POB02;Ribociclib-2;PALBOCICLIB4
- CBNumber:
- CB62464781
- Summenformel:
- C14H22N4O2
- Molgewicht:
- 278.35
- MOL-Datei:
- 571188-59-5.mol
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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Eigenschaften
- Schmelzpunkt:
- 130-132℃
- Siedepunkt:
- 454.1±45.0 °C(Predicted)
- Dichte
- 1.182
- Dampfdruck
- 0-0Pa at 20-25℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Very Slightly)
- Aggregatzustand
- Solid
- pka
- 7.36±0.26(Predicted)
- Farbe
- Dark Yellow
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16)
- InChIKey
- RMULRXHUNOVPEI-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1
- LogP
- 1.6-1.8 at 35℃ and pH7-9
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.
Verwenden
4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.
synthetische
4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.
Pharmazeutische Anwendungen
tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is an organic compound. It has been shown to inhibit the growth of cancer cells in vitro and in vivo, and is being investigated as a potential treatment for breast cancer.
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 589)Lieferanten
571188-59-5()Verwandte Suche:
- 1-Piperazinecarboxylic acid, 4-(6-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
- tert-butyl 4-(6-aMinopyri
- 4-(6-AMinopyridin-3-yl)-1-Boc-piperazine
- tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate(For Palbociclib)
- Palbociclib's intermediate
- 4-(6-aMinopyridin-3-yl)p
- t-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)
- Palbociclib Intermediate
- Ribociclib-2
- tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
- Tert-Butyl 4-(6-Amino-3-Pyrimidin)Piperazine-1-Carboxylate
- 4-(6-Amino-3-pyridyl)piperazine-1-carboxylic Acid tert-Butyl Ester
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- PALBOCICLIB4
- 2-Methyl-2-propanyl 4-(6-amino-3-pyridinyl)-1-piperazinecarboxylate
- 6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected 98%
- 1-Butyloxycarbonyl-4-(6-aminopyridin-3-yl)-piperazine
- Palbociclib Impurity 68
- Palbociclib-018
- Palbociclib-11
- Tert-buty 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
- POB02
- OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine
- tert-butyl 4-(6-aminoyridin-3-yl)pipera-zine-1-carboxylate
- OTAVA-BB 1207229
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- 1-(tert-Butoxycarbonyl)-4-(6-aminopyridin-3-yl)piperazine
- Palbociclib Intermediate 1, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine(571188-59-5)
- 4-(6-Amino-3-pyridyl)-1-Boc-piperazine
- 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZIN
- tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >
- 4-(6-aminopyridine-3-yl) piperazine-1-carboxylic tert-butyl ester
- )piperazine-1-carboxyL
- Ribociclib Related Compound 1
- Tert-Butyl 4-(6-aminopyridin-3-piperazine-1-carboxylate
- 4-(6- aminopyridine -3- yl) piperazine -1- tert-butyl carboxylate
- ert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- 1-tert-Butoxycarbonyl-4-(6-amino-3-pyridyl)piperazine
- OTAVA-BB 1207229
- 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester
- OTAVA-BB
- 1-Boc-4-(6-amino-3-pyridyl)piperazine
- 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- Palbociclib side chain
- 4- (6-aminopyridine-3-yl) piperazin-1-carboxylic acid tert-butyl ester
- tert-Butyl-4-(6-aminopyridin-3-yl)piperazin-1-carboxylate
- 4-(6-AMinopyridin-3-yl)-1-Boc-piperazin
- 6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected
- Tert-butyl 4-(6-aminopyridine-3-yl)piperazine-1-carbaxylate
- 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert butyl ester(OTAVA-BB 1207229)
- 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
- 4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic
- tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
- 571188-59-5
- 571188-59-9
- PD 0332991
- Palbociclib
