tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- CAS No.
- 571188-59-5
- Chemical Name:
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- Synonyms
- 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;OTAVA-BB 1207229;1-Boc-4-(6-amino-3-pyridyl)piperazine;4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic;POB02;Ribociclib-2;PALBOCICLIB4
- CBNumber:
- CB62464781
- Molecular Formula:
- C14H22N4O2
- Molecular Weight:
- 278.35
- MDL Number:
- MFCD11594962
- MOL File:
- 571188-59-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >98.0%(HPLC)(T) | B4669 | 200mg | $68 |
| tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >98.0%(HPLC)(T) | B4669 | 1g | $239 |
| tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Asreported | 263605 | 100mg | $418 |
| tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Asreported | 263605 | 250mg | $672 |
| tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Asreported | 263605 | 500mg | $955 |
| More product size | |||
| Melting point | 130-132℃ |
|---|---|
| Boiling point | 454.1±45.0 °C(Predicted) |
| Density | 1.182 |
| vapor pressure | 0-0Pa at 20-25℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Very Slightly) |
| form | Solid |
| pka | 7.36±0.26(Predicted) |
| color | Dark Yellow |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16) |
| InChIKey | RMULRXHUNOVPEI-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1 |
| LogP | 1.6-1.8 at 35℃ and pH7-9 |
| FDA UNII | 6Y3BU8W3TC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2933599590 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4669 | tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >98.0%(HPLC)(T) | 571188-59-5 | 200mg | $68 | 2025-07-31 | Buy |
| TCI Chemical | B4669 | tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >98.0%(HPLC)(T) | 571188-59-5 | 1g | $239 | 2024-03-01 | Buy |
| Usbiological | 263605 | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Asreported | 571188-59-5 | 100mg | $418 | 2026-06-03 | Buy |
| Usbiological | 263605 | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Asreported | 571188-59-5 | 250mg | $672 | 2026-06-03 | Buy |
| Usbiological | 263605 | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Asreported | 571188-59-5 | 500mg | $955 | 2026-06-03 | Buy |
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemical Properties,Uses,Production
Physical Form
Solid
Description
Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.
Uses
4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.
Preparation
4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.
Hazard
Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation
Pharmaceutical Applications
tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is an organic compound. It has been shown to inhibit the growth of cancer cells in vitro and in vivo, and is being investigated as a potential treatment for breast cancer.
Synthesis
571189-16-7
571188-59-5
General Steps: Example 101h Synthesis of tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate 101h To a 500 mL triple-necked vial under nitrogen protection was added tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate 101g (3.1 g, 10 mmol), 10% palladium-carbon catalyst (50% wet, 1.0 g) and anhydrous ethanol (100 mL). The reaction system was evacuated and filled with hydrogen, and the reaction was stirred at room temperature for 16 hours. Upon completion of the reaction, the hydrogen was removed by evacuation and refilled with nitrogen for protection. The reaction mixture was filtered through a diatomaceous earth pad to remove the catalyst and the filtrate was concentrated under reduced pressure to give the target compound 101h (2.7 g, 97% yield). Mass spectral data: MS: [M + H]+ 279.
References
[1] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 6, p. 3125 - 3140
[2] Patent: WO2016/30439, 2016, A1. Location in patent: Page/Page column 30
[3] Patent: WO2011/140488, 2011, A1. Location in patent: Page/Page column 112; 270
[4] Patent: US2013/116262, 2013, A1. Location in patent: Paragraph 0315
[5] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0170; 0171; 1405
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Qiwei Pharmatech Co.,Ltd | 13282840061 | mw@qwpharmatech.com | China | 109 | 58 |
| ChemExpress | +86-19370970350 +86-021-58950125 | info@chemexpress.com | China | 788 | 58 |
| SHANDONG BOYUAN PHARMACEUTICAL CO., LTD. | +86-531-88625728 +86-15806417970 | sales@boyuanpharm.com | China | 181 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +86-18627785180 | info@finetechnology-ind.com | China | 9539 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Shanghai Joiny Pharmaceutical Co.,LTD | +86-13681955282 | gyd@joiny-pharma.com | China | 402 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +86-18627948422 | sale@hdimpurity.com | China | 3681 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
Related articles
- Chemical Property of Tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
- Tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is primarily used as a pharmaceutical chemical intermediate.
- Mar 15，2026
View Lastest Price from tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-31 | Palbociclib side chain
571188-59-5
|
2Kg/Bag | 0.98 | 20 tons | Sinoway Industrial co., ltd. | ||
 |
2026-07-16 | tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
571188-59-5
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-06-08 | tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
571188-59-5
|
1kg | 99% | 1 | Jinan Ruitong Biotech Co., Ltd. |
-
- Palbociclib side chain
571188-59-5
- 0.98
- Sinoway Industrial co., ltd.
-
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
571188-59-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
571188-59-5
- 99%
- Jinan Ruitong Biotech Co., Ltd.
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