1-BOC-Piperazine
- CAS No.
- 57260-71-6
- Chemical Name:
- 1-BOC-Piperazine
- Synonyms
- 1-BOC-PIPERAZINE;BOC-PIPERAZINE;N-BOC-PIPERAZINE;PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 1-PIPERAZINECARBOXYLATE;1-N-BOC-PIPERAZINE;1-(TERT-BUTOXYCARBONYL)PIPERAZINE;N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE;TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CARBOXYLATE;PIBOC
- CBNumber:
- CB8268275
- Molecular Formula:
- C9H18N2O2
- Molecular Weight:
- 186.25
- MDL Number:
- MFCD00075265
- MOL File:
- 57260-71-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-Boc-piperazine ≥98.0% (GC) | 15502 | 5g | $122 |
| 1-Boc-piperazine ≥98.0% (GC) | 15502 | 25g | $291 |
| 1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) | B2415 | 5g | $71 |
| 1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) | B2415 | 25g | $228 |
| 1-Boc-piperazine ≥99%(GC) | 31386 | 25G | $18.5 |
| More product size | |||
| Melting point | 43-47 °C(lit.) |
|---|---|
| Boiling point | 98-100 |
| Density | 1.030±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO |
| pka | 8.45±0.10(Predicted) |
| form | Low Melting Crystalline Mass |
| color | White to light yellow |
| Water Solubility | Soluble in ethyl acetate, methanol and water. |
| Sensitive | Air Sensitive |
| BRN | 879985 |
| InChI | 1S/C9H18N2O2/c1-9(2,3)13-8(12)11-6-4-10-5-7-11/h10H,4-7H2,1-3H3 |
| InChIKey | CWXPZXBSDSIRCS-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)N1CCNCC1 |
| CAS DataBase Reference | 57260-71-6(CAS DataBase Reference) |
| FDA UNII | LBC2X3S28C |
| NIST Chemistry Reference | T-butyl 1-piperaziencarboxylate(57260-71-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3263 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10-34 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335995 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
1-BOC-Piperazine price More Price(100)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 15502 | 1-Boc-piperazine ≥98.0% (GC) | 57260-71-6 | 5g | $122 | 2026-04-30 | Buy |
| Sigma-Aldrich | 15502 | 1-Boc-piperazine ≥98.0% (GC) | 57260-71-6 | 25g | $291 | 2026-04-30 | Buy |
| TCI Chemical | B2415 | 1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) | 57260-71-6 | 5g | $71 | 2026-04-30 | Buy |
| TCI Chemical | B2415 | 1-(tert-Butoxycarbonyl)piperazine >98.0%(GC)(T) | 57260-71-6 | 25g | $228 | 2026-04-30 | Buy |
| Chem-Impex | 31386 | 1-Boc-piperazine ≥99%(GC) | 57260-71-6 | 25G | $18.5 | 2026-05-19 | Buy |
1-BOC-Piperazine Chemical Properties,Uses,Production
Uses
N-Boc-piperazine is a compound useful in organic synthesis.
Chemical Properties
Waxy Solid
Uses
1-Boc-piperazine may be used in:
- preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
- termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
- preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors
Uses
1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.
Application
Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.
General Description
1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.
Synthesis
The current method of synthesizing 1-tert-butoxycarbonylpiperazine is mainly to use anhydrous piperazine drops with di-tert-butyl dicarbonate selective reaction of the nitrogen at one end of the piperazine is protected so that the other end of the amino group to go to the reaction with the other group, so that the method of reaction, the piperazine will be connected to the ends of the di-tert-butyl dicarbonate, the purification of the purity of the piperazine must be washed with a large amount of water.
1-BOC-Piperazine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | sales01@jndxj.com | China | 296 | 58 |
| Nanjing Sinoda Biological Technology Co., Ltd | +8613401983379 | sales@njmcn.cn | CHINA | 74 | 58 |
| BTC pharm India | +918790379245 | banny.janga@btcpharm.com | India | 1262 | 58 |
| Guangzhou Tosun Pharmaceutical Limited | +86-18124244216 +86-18124244216 | info@upharm.cn | China | 998 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 286 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20122 | 58 |
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- Different applications of 1-tert-Butoxycarbonylpiperazine
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View Lastest Price from 1-BOC-Piperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-18 | 1-BOC-Piperazine
57260-71-6
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2026-03-20 | tert-Butyl 1-piperazinecarboxylate
57260-71-6
|
$19.90 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-12-01 | 1-BOC-Piperazine
57260-71-6
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 1-BOC-Piperazine
57260-71-6
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- tert-Butyl 1-piperazinecarboxylate
57260-71-6
- $19.90
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 1-BOC-Piperazine
57260-71-6
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
