ChemicalBook >> CAS DataBase List >>6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one structure

CAS No.: 1016636-76-2

Chemical Name:: 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

Synonyms: 6-BroMo-2-chloro-8-cyclopentyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one;Palbociclib-015;6-broMo-2-chloro-8-cyclopentyl-5-;6-bromo-2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one;PALBOCI;PALBOCICLIB-PB3;Palbociclib nuclear;Pabucilib impurity 8;Palbociclib Impurity I;Palbociclib Intermediate 3

CBNumber:: CB32554175

Molecular Formula:: C13H13BrClN3O

Molecular Weight:: 342.62

MDL Number:: MFCD13181208

MOL File:: 1016636-76-2.mol

MSDS File:: SDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one	TRC-B682195-250MG	250mg	$205
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one	TRC-B682195-1G	1g	$613
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one	TRC-B682195-100MG	100mg	$109
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one	FB138812	5g	$900
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one	FB138812	50g	$900
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6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Properties

Melting point	190-192°C
Boiling point	468.4±45.0 °C(Predicted)
Density	1.645±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	-0.61±0.20(Predicted)
color	White
InChI	InChI=1S/C13H13BrClN3O/c1-7-9-6-16-13(15)17-11(9)18(12(19)10(7)14)8-4-2-3-5-8/h6,8H,2-5H2,1H3
InChIKey	HJQCAEDIUJXGCQ-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C2C(C)=C(Br)C(=O)N(C3CCCC3)C2=N1
FDA UNII	6SDD8U5F6G
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317-H319
Precautionary statements	P280-P305+P351+P338
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN2811
REACH Registrations	Active

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-B682195-250MG	6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one	1016636-76-2	250mg	$205	2026-06-03	Buy
TRC	TRC-B682195-1G	6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one	1016636-76-2	1g	$613	2026-06-03	Buy
TRC	TRC-B682195-100MG	6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one	1016636-76-2	100mg	$109	2026-06-03	Buy
Biosynth	FB138812	6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one	1016636-76-2	5g	$900	2026-06-04	Buy
Biosynth	FB138812	6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one	1016636-76-2	50g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-B682195-250MG	250mg	$205	Buy
TRC-B682195-1G	1g	$613	Buy
TRC-B682195-100MG	100mg	$109	Buy
FB138812	5g	$900	Buy
FB138812	50g	$900	Buy

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Chemical Properties,Uses,Production

Use

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one is used to prepare pyridino[2,3-d]pyrimidin-7(8H)-one derivatives as CDK4 and/or CDK6 inhibitors useful in the treatment of diseases.

Description

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one is a pharmaceutical intermediate that can be used to synthesize Palbociclib, an inhibitor of cyclin-dependent kinases (CDKs) 4 and 6 for the treatment of breast cancer.

Chemical Properties

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one is a White Solid. Slightly soluble in methanol, chloroform and DMSO.

General Description

6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one is a key intermediate in the synthesis of Ibrance^[1]. The structural feature of this compound lies in its incorporation of two functional groups—bromine and chlorine—which heighten its reactivity during synthesis. Furthermore, it may also be employed in the synthesis of palbociclib and its salt derivatives^[2].

References

[1] HANHAN XU. Solid–Liquid Equilibrium and Thermodynamic Properties of 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3]pyrimidin-7(8H)-one in 10 Pure Solvents and 3 Different Miscible Systems at T = (278.15–323.15) K[J]. Journal of Chemical & Engineering Data, 2021, 66 8: 3323-3334. DOI:10.1021/acs.jced.1c00362.
[2] KOCIE?SKI P. Synthesis of Palbociclib[J]. Synfacts, 2016, 60 1: 1012-1012. DOI:10.1055/S-0036-1589195.

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Suppliers

Global( 520)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Senova Technology Co. Ltd.	+86-0755-86703119 +86-18503098836	info@senovatech.com	China	351	58
AstaTech(Chengdu) Biopharmaceutical Corp.	+86-02882666559 +86-15884417729	gjpu@astatech.com.cn	China	308	58
ChemExpress	+86-19370970350 +86-021-58950125	info@chemexpress.com	China	788	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40066	58
Shanghai Joiny Pharmaceutical Co.,LTD	+86-13681955282	gyd@joiny-pharma.com	China	402	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	+86-531-88625728 +86-15806417970	sales@boyuanpharm.com	China	181	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	+86-18627948422	sale@hdimpurity.com	China	3681	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55

Supplier	Advantage
Senova Technology Co. Ltd.	58
AstaTech(Chengdu) Biopharmaceutical Corp.	58
ChemExpress	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	58
Shanghai Joiny Pharmaceutical Co.,LTD	58
Hangzhou ICH Biofarm Co., Ltd	58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55

View Lastest Price from 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-31	6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2		1KG	99%min	100kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-27	Palbociclib Impurity 8 1016636-76-2		1KG	99%	1000kgs	Shaanxi Dideu New Materials Co. Ltd
2026-07-24	6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one 1016636-76-2	$14.00	1ASSAYS	99%	20mt	Jinan Finer Chemical Co., Ltd

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
1016636-76-2
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

Palbociclib Impurity 8
1016636-76-2
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one
1016636-76-2
$14.00
99%
Jinan Finer Chemical Co., Ltd

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Spectrum

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(1016636-76-2)¹HNMR

1016636-76-2(6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one)Related Search:

6-broMo-4,4-diMethyl-3,4-dihydronaphthalen-1(2H)-one tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Palbociclib Impurity N Palbociclib Impurity D

5-(piperazin-1-yl)pyridin-2-aMine Palbociclib-012 5-bromo-4-chloro-N-cyclopentylpyrimidin-2-amine 6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one Ezetimibe

(4S)-3-[(5R)-5-(4-FLUOROPHENYL)-5-HYDROXYPENTANOYL]-4-PHENYL-1,3-OXAZOLIDIN-2-ONE 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde pyridine-3-sulfonyl chloride 4-[[(4-Fluorophenyl)imino]methyl]-phenol Flupirtine maleate

5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one sacubitril 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-

1of4

6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-on 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-broMo-2-chloro-8-cyclopentyl-5-Methyl- PALBOCICLIB-PB3 6-bromo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(For Palbociclib) 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one PALBOCI 6-bromo-2-chloro-8-cyclopentyl-5-methylpyridino[2,3-d]pyrimidin-7(8H)-one Palbociclib Intermediate 3 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(1016636-76-2) Palbociclib Impurity I 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2 -broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one ISO 9001：2015 REACH 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido {2,3} pyrimidin-7-(8H)-one 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H) 6-bromo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 6- 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidi... 6-broMo-2-chloro-8-cyclopentyl-5- 6-bromo-2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one Palbociclib nuclear 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(9H)-one 6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido {2,3} pyrimidine-7-(8H)-one 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3- Pabucilib impurity 8 1016636-76-26-Bromo-2-chloro-8-cyclopentyl-5-methyl-pyrido[2,3-D]pyrimidin-7(8H)-one 6-BroMo-2-chloro-8-cyclopentyl-5-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one Palbociclib-015 1016636-76-2 1016636-76-3 2174002-19-8 Palbociclib PD 0332991 Anticancer 1016636-76-2

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