PF-04457845

1020315-31-4

CAS-Nr.: 1020315-31-4

Englisch Name:: PF-04457845

Synonyma:: CS-1549;PF-04457845;Redafamdastat;PF-04457845;PF04457845;PF-04457845 >=98% (HPLC);PF-04457845, 10 mM in DMSO;Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor;N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide;N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide;N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide

CBNumber:: CB62522724

Summenformel:: C23H20F3N5O2

Molgewicht:: 455.43

MOL-Datei:: 1020315-31-4.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 94

PF-04457845 Eigenschaften

Siedepunkt:: 687.0±55.0 °C(Predicted)

Dichte: 1.389±0.06 g/cm3(Predicted)

storage temp.: room temp

L?slichkeit: DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml

pka: 12.72±0.20(Predicted)

Aggregatzustand: powder

Farbe: white to beige

InChI: 1S/C23H20F3N5O2/c24-23(25,26)18-6-7-21(27-15-18)33-19-4-1-3-17(14-19)13-16-8-11-31(12-9-16)22(32)29-20-5-2-10-28-30-20/h1-7,10,13-15H,8-9,11-12H2,(H,29,30,32)

InChIKey: BATCTBJIJJEPHM-UHFFFAOYSA-N

SMILES: O=C(NC1=NN=CC=C1)N(CC2)CCC2=CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3

Sicherheit

WGK Germany	3
Speicherklasse	11 - Combustible Solids

PF-04457845 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

PF-04457845 is a potent, orally active, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. PF-04457845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It was shown to be both potent and selective against other serine hydrolases. It has an IC50 value of 7.2 nM for human FAAH. The endocannabinoid system is a target for therapeutic pain relief. In a rat model of inflammatory pain, PF-04457845 produced significant reduction of inflammatory pain with efficacy comparable to that of naproxen at 10 mg/kg.

PF-04457845 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Pyridine, 2-[3-(4-piperidinylidenemethyl)phenoxy]-5-(trifluoromethyl)-, hydrochloride (1:1) Phosphonic acid, P-[[3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]phenyl]Methyl]-, diethyl ester CarbaMic acid, N-3-pyridazinyl-, phenyl ester BenzeneMethanol, 3-[[5-(trifluoroMethyl)-2-pyridinyl]oxy]- Pyridine, 2-[3-(chloroMethyl)phenoxy]-5-(trifluoroMethyl)- 3-Hydroxybenzylalkohol 2-Chlor-5-(trifluormethyl)pyridin Ethyldiisopropylamin Acetonitril

Downstream Produkte

PF-04457845 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 94)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19853	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39040	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43333	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

N-3-Pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methylene]-1-piperidinecarboxamide
PF-04457845
N-Pyridazin-3-yl-4-(3-{[5-(trifluoroMethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxaMide
PF-04457845;PF04457845
1-Piperidinecarboxamide, n-3-pyridazinyl-4-[[3-[[5-(trifluoromethyl)-2- pyridinyl]oxy]phenyl]methylene]-
N-pyridazin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methylidene]piperidine-1-carboxamide
CS-1549
PF-04457845 >=98% (HPLC)
Fatty acid amide hydrolase,Autophagy,inhibit,PF-04457845,FAAH,Inhibitor
PF-04457845, 10 mM in DMSO
Redafamdastat
1020315-31-4
C23H20F3N5O2

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