Pramipexole Impurity 4
|
|
|
- CAS-Nr.
- 104632-25-9
- Englisch Name:
- Pramipexole Impurity 4
- Synonyma:
- PRAMIPEXOLE DIHYDROCHLORIDE;PRAMIPEXOLE HYDROCHLORIDE;PRAMIPEXOLE HCL;CS-296;Praxole;PRAMPEXOL HCL;PRAMIPEXOL HCL;PramipexoleDihcl;Pramepexole 2HCl;Crufomate Impurity 4
- CBNumber:
- CB6291554
- Summenformel:
- C10H19Cl2N3S
- Molgewicht:
- 284.25
- MOL-Datei:
- 104632-25-9.mol
|
Pramipexole Impurity 4 Eigenschaften
- Schmelzpunkt:
- 288-290°C
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: >20mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Wasserl?slichkeit
- H2O: >20mg/mL
- InChI
- 1S/C10H17N3S.2ClH/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H/t7-;;/m0../s1
- InChIKey
- QMNWXHSYPXQFSK-KLXURFKVSA-N
- SMILES
- Cl.Cl.CCCN[C@H]1CCc2nc(N)sc2C1
- CAS Datenbank
- 104632-25-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
|
|
| Speicherklasse |
11 - Combustible Solids |
|
|
| Hazard Classifications |
Acute Tox. 4 Oral
STOT SE 3 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung
|
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
|
P264, P270, P301+P312, P330, P501 |
| H336 |
Kann Schl?frigkeit und Benommenheit verursachen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Schl?frigkeit und Benommenheit) |
Warnung |
|
P261, P271, P304+P340, P312,P403+P233, P405, P501 |
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
|
Pramipexole Impurity 4 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Mirapex, an non ergot derivative, was launched in the US for treatment of
Parkinson's disease. It can be prepared by two related routes, 5 steps and 3 steps,
both involving an optical resolution with L-(+)-tartaric acid to afford the (S)-isomer.
Mechanistically, it is a presynaptic dopamine D
2 autoreceptor agonist which also
activates D
3-receptors. It is well absorbed from the GI and excreted in the urine
essentially unchanged with a half-life of 8-12 hr. Mirapex had favorable effects on the
symptoms without levodopa for patients with advanced PD and allowed a 27%
reduction in use of levodopa in combination therapy. It had an adverse events profile
similar to other dopamine agonists and in advanced patients reduced the mean "on-off"
hr/day from 6 to 4. It was safe but not efficacious in all patients.
Chemische Eigenschaften
White Crystalline Powder
Definition
ChEBI: A hydrochloride that is the anhydrous dihydrochloride salt of pramipexole.
Allgemeine Beschreibung
Pramipexole dihydrochloride,(S)-2-amino-6-propylamino-dihydrochloride(Mirapex), is a white to off-white powder soluble in water,slightly soluble in methanol and ethanol, and practically insolublein dichloromethane. Following oral administration,pramipexole is readily absorbed. Pharmacokinetic propertiesdiffer between men and women, with area under the curve(AUC) for each dose level being 35% to 43% greater inwomen, mainly because of a 24% to 27% lower oral clearance.The drug undergoes minimal hepatic biotransformationand is excreted virtually unchanged in the urine by the renaltubular secretion. Pramipexole interacts with drugs excretedby renal tubular secretion (H2-antagonists, diuretics, verapamil,quinidine, quinine), which leads to a decreased clearanceof pramipexole.44,45 Pramipexole is indicated fortreatment of the signs and symptoms of idiopathic PD, aloneor in combination with levodopa. It is also indicated for symptomatictreatment of moderate to severe idiopathic restlesslegs syndrome (RLS).
Pramipexole Impurity 4 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Pramipexole Impurity 4 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 354)Lieferanten
104632-25-9()Verwandte Suche:
- PRAMIPEXOL HCL
- (s)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
- PramipexoleDihcl
- (S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol2HCltetrahydrobenzothiazol
- (s)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine, Dihydrochloride
- Pramipexole dihydrochloride
(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
- PraMipexole dihydrochlor
- 2,6-BenzothiazolediaMine, 4,5,6,7-tetrahydro-N6-propyl-, hydrochloride (1:2), (6S)-
- (S)-Pramipexole Dihydrochloride
- (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine dihydrochloride
- 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (6S)-
- 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (S)-
- Pramipexole dihydrochloride [usan]
- 2,6-BenzothiazolediaMine,4,5,6,7-tetrahydro-N6-propyl-, hydrochl
- pramipexole hydrochloride anhydrous
- CS-296
- Pramipexole dihydrochloride(USP)
- Pramipexole Impurity 4 USP/EP/BP
- Pramipexole dihydrochloride salt
- Pramepexole 2HCl
- Pramipexole dihydrochlorideQ: What is
Pramipexole dihydrochloride Q: What is the CAS Number of
Pramipexole dihydrochloride Q: What is the storage condition of
Pramipexole dihydrochloride
- (S)-Pramipexole-d7 Dihydrochoride
- Praxole
- Benzoicacid,3-bromo-6-ethyl-
- (S)-Pramipexole (hydrochloride)
- PRAMPEXOL HCL
- Crufomate Impurity 4
- Pramipexole dihydrochloride, Dopamine D2-like receptor agonist. D3-preferring.
- Pramipexole Impurity 83 DiHCl
- PRAMIPEXOLE DIHYDROCHLORIDE
- PRAMIPEXOLE HYDROCHLORIDE
- PRAMIPEXOLE HCL
- 104632-25-9
- C10H17N3S2HCl
- C10H17N3S2ClH
- C10H19Cl2N3S
- Chiral Reagents
- Sulfur & Selenium Compounds
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
- APIs
- Antiparkinsonian
- All Inhibitors
- 104632-25-9
