Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Tolmetin Sodium is a non-steroidal anti-inflammatory drug.

Pharmakokinetik

Tolmetin sodium is rapidly and almost completely absorbed on oral administration, with peak plasma levels being attained within the first hour of administration. It has a relatively short plasma half-life of approximately 1 hour because of extensive first-pass metabolism, involving hydroxylation of the p-methyl group to the primary alcohol, which is subsequently oxidized to the dicarboxylic acid.

Clinical Use

Tolmetin is synthesized straightforwardly from 1-methylpyrrole. It was introduced in the United States in 1976 and like other NSAIDs, inhibits prostaglandin biosynthesis. Tolmetin, however, also inhibits polymorph migration and decreases capillary permeability. Its anti-inflammatory activity, as measured in the carrageenan-induced rat paw edema and cotton pellet granuloma assays, is intermediate between those of phenylbutazone and indomethacin.

Nebenwirkungen

The most frequently adverse reactions are those involving the GI tract (e.g., abdominal pain, discomfort, and nausea) but appear to be less than those observed with aspirin. The CNS effects (e.g., dizziness and drowsiness) also are observed. Few cases of overdosage have been reported, but in such cases, recommended treatment includes elimination of the drug from the GI tract by emesis or gastric lavage and elimination of the acidic drug from the circulatory system by enhancing alkalinization of the urine with sodium bicarbonate.

Stoffwechsel

This metabolite is inactive in standard in vivo anti-inflammatory assays. The free acid (pKa = 3.5) is highly bound to plasma proteins (99%), and excretion of tolmetin and its metabolites occurs primarily in the urine.Approximately 15 to 20% of an administered dose is excreted unchanged and 10% as the glucuronide conjugate of the parent drug. Conjugates of the dicarboxylic acid metabolite account for the majority of the remaining administered drug.

Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30225	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20581	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49968	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	19956	58
Chongqing jooe co., ltd	+undefined86-15223382610	info@jooe.com	China	15976	58
Hangzhou Yuhao Chemical Technology Co., Ltd	0571-82693216	info@yuhaochemical.com	China	6387	52
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12335	58
Shanghai Hekang Biotechnology Co., Ltd.	17721021104 18939837085	2880152141@qq.com	China	1839	55

35711-34-3(Natrium-1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-acetat)Verwandte Suche:

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• TOLMETIN SODIUM
• sodium 1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate
• TOLECTIN
• 1-Methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid sodium salt
• 1-Methyl-5-p-toluoyl-1H-pyrrole-2-acetic acid sodium salt
• Sodium tolmetin
• SodiuM 2-(1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl)acetate
• tolmetin sodium:sodium 1-methyl-5-(4-methylbenzoyl)-1h-pyrrole-2-acetate
• sodium:2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate
• Tolmetin Sodium Salt
• Tolmetin sodium USP/EP/BP
• TOLMETIN SODIUM USP
• 35711-34-3