Sarpogrelate hydrochloride
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- CAS-Nr.
- 135159-51-2
- Englisch Name:
- Sarpogrelate hydrochloride
- Synonyma:
- SARPOGRELATE HCL;Anplag;MCI 9042;LS187,118;LS 187,118;LS-187,118;Sarpogrelate-D3 HCl;Sarpogrelate hydroch;SARPOGRELATE HYDROCHLORIDE;Sarpogrelate HCl - Bio-X ?
- CBNumber:
- CB6511456
- Summenformel:
- C24H32ClNO6
- Molgewicht:
- 465.96698
- MOL-Datei:
- 135159-51-2.mol
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Sarpogrelate hydrochloride Eigenschaften
- Schmelzpunkt:
- 145-148°C
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- deionized water: ≥5mg/mL
- Aggregatzustand
- solid
- Farbe
- White to off-white
- InChI
- InChI=1S/C24H31NO6.ClH/c1-25(2)16-21(31-24(28)14-13-23(26)27)17-30-22-10-5-4-8-19(22)12-11-18-7-6-9-20(15-18)29-3;/h4-10,15,21H,11-14,16-17H2,1-3H3,(H,26,27);1H
- InChIKey
- POQBIDFFYCYHOB-UHFFFAOYSA-N
- SMILES
- C1(C=CC=CC=1CCC1C=CC=C(OC)C=1)OCC(CN(C)C)OC(=O)CCC(=O)O.Cl
- CAS Datenbank
- 135159-51-2(CAS DataBase Reference)
Sarpogrelate hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Sarpogrelate hydrochloride, a potent and selective serotonin 5-HT
2 receptor
antagonist, was launched in Japan as an antithrombotic. It exhibits inhibition of ex vivo
platelet aggregation stimulated by serotonin in combination with collagen and suppression of
blood vessel constriction mediated by 5-HT
2 in vitro. Its antithrombotic effects have been
demonstrated in several in vivo experimental models including reduction of the mortality rate in
acute pulmonary thromboembolic disease, arterial thrombosis, and peripheral obstructive
disease. Sarpogrelate has been shown to be especially useful as an antiplatelet agent for
patients with Type 2 diabetes mellitus, in whom 5-HT
2mediated amplification of collageninduced
platelet aggregation is significantly increased.
Chemische Eigenschaften
White Solid
Verwenden
Sarpogrelate hydrochloride is a potent and selective 5-HT2A receptor antagonist
ress-induced hemolysis.
Biologische Aktivit?t
Selective 5-HT 2A receptor antagonist (pK i values are 8.52, 7.43 and 6.57 for 5-HT 2A , 5-HT 2C and 5-HT 2B receptors respectively). Displays selectivity over 5-HT 1 , 5-HT 3 , 5-HT 4 H 1 , H 2 , M 3 , α 1 -adrenergic, α 2 -adrenergic and β -adrenergic receptors. Displays cardioprotective activity in vivo .
Sarpogrelate hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Sarpogrelate hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 298)Lieferanten
135159-51-2()Verwandte Suche:
- Sarpogrelate-D3 HCl
- Anplag
- Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride (9CI)
- Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester, hydrochloride, (+-)-
- MCI 9042
- 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid hydrochloride
- 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxo-butanoic acid hydrochloride
- 4-[1-(dimethylaminomethyl)-2-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]ethoxy]-4-keto-butyric acid hydrochloride
- Succinicacidmono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)ethyl]phenoxy)ethyl)esterhydrochloride
- Butanedioic acid 1-[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester hydrochloride
- Succinic acid mono-(1-dimethylaminomethyl-2-(2-[2-(3-methoxyphenyl)et hyl]phenoxy)ethyl) ester hydro
- SARPOGRELATE HYDROCHLORIDE
- (+/-)-2-(dimethylamino)-1-{[o-(m-methoxyphenethyl)phenoxy]methyl}ethyl hydrogen succinate hydrochloride
- 4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}pr
- Sarpogrelate Hydrochloride intermediate
- 4-{[1-(dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}propan-2-yl]oxy}-4-oxobutanoic acid hydrochloride (1:1)
- Sarpogrelate hydrochloride, >=99%
- 4-((1-(dimethylamino)-3-(2-(3-methoxyphenethyl)phenoxy)propan-2-yl)oxy)-4-oxobutanoic acid hydrochloride
- Butanedioic acid, mono[2-(dimethylamino)-1-[[
- ANPLAG;MCI 9042;MCI9042;MCI-9042
- Sarpogrelate Hydrochloride
（mixture of isomers）
- Sarpogrelate Hydrochloride RS
- Sarpogrelate hydrochloride USP/EP/BP
- Sarpogrelate hydroch
- Sarpogrelate HydrochlorideQ: What is
Sarpogrelate Hydrochloride Q: What is the CAS Number of
Sarpogrelate Hydrochloride Q: What is the storage condition of
Sarpogrelate Hydrochloride
- LS 187,118
- LS187,118
- LS-187,118
- Sarpogrelate hydrochloride, 10 mM in DMSO
- Sarpogrelate HCl - Bio-X ?
- (+/-)-2-(dimethylamino)-1-{[o-(m-methoxyphenethyl)phenoxy]methyl}ethyl hydrogen succinate hydrochloride
- SARPOGRELATE HCL
- 135159-51-2
- C24H31NO6HCl
- C24H32ClNO6
- strong recommend
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