Esomeprazole
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- CAS-Nr.
- 119141-88-7
- Englisch Name:
- Esomeprazole
- Synonyma:
- Esomeprazol;EsoMaprozole;5-Methoxy-2-(4-Methoxy-3,5-diMethyl-pyridin-2-ylMethanesulfinyl)-1H-benzoiMidazole;5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole;(R)-5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole;(S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole;(RelCpd F);119141-58-6;Esomeprzole;Esomeprazole
- CBNumber:
- CB6740618
- Summenformel:
- C17H19N3O3S
- Molgewicht:
- 345.42
- MOL-Datei:
- 119141-88-7.mol
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Esomeprazole Eigenschaften
- alpha
- D20 -155° (c = 0.5 in chloroform)
- Siedepunkt:
- 600.0±60.0 °C(Predicted)
- Dichte
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- L?slichkeit
- DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml
- Aggregatzustand
- A solid
- pka
- 8.50±0.10(Predicted)
- Aussehen
- Brown to reddish brown Solid
- Henry's Law Constant
- 3.3×1013 mol/(m3Pa) at 25℃, HSDB (2015)
- InChI
- InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/t24-/m0/s1
- InChIKey
- SUBDBMMJDZJVOS-DEOSSOPVSA-N
- SMILES
- C1([S@](CC2=NC=C(C)C(OC)=C2C)=O)NC2=CC(OC)=CC=C2N=1
- CAS Datenbank
- 119141-88-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H312 |
Gesundheitssch?dlich bei Hautkontakt. |
Akute Toxizit?t dermal |
Kategorie 4 |
Warnung |
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P280,P302+P352, P312, P322, P363,P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P321 |
Besondere Behandlung |
| P322 |
Gezielte Ma?nahmen |
| P332 |
Bei Hautreizung |
| P363 |
Kontaminierte Kleidung vor erneutem Tragen waschen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Esomeprazole Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Esomeprazole, formulated as a magnesium salt, reached the market as a treatment for
acid-related diseases such as gastro-esophageal reflux (GERD) disease including peptic
ulcer disease and reflux esophagitis. Esomeprazole (formerly perprazole) is the active (S)-
enantiomer of omeprazole (1988) and the first proton pump inhibitor developed as an
optical isomer. It can be obtained by several routes such as asymmetric oxidation of the
pro-chiral pyridylmethyl benzimidazole sulfide, separation from the racemic sulfoxide by
chiral chromatography or separation of a diastereomeric mixture obtained from the racemic
compound and a chiral acid, followed by hydrolysis. Biochemical studies have shown that
esomeprazole irreversibly inhibits the gastric H
+/K
+-adenosine triphosphatase (ATPase),
an enzyme system involved at the secretory surface of the stomach’s parietal cells
responsible for the secretion of gastric acid. Compared with racemic omeprazole in healthy
subjects, esomeprazole has higher bioavailability, is absorbed more rapidly and exhibits a
more uniform and predictable dose-response with higher plasma levels, leading to less
inter-individual variability between slow and rapid metabolizers. In extensive clinical trials
in patients suffering from GERD symptoms, esomeprazole provided superior acid control
and significantly reduced the healing time compared to omeprazole.
Verwenden
(-)-Omeprazole can be used to treat migraine.
Verwenden
Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough.
Definition
ChEBI: A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has S configuration at the sulfur atom. An inhibitor of gastric acid secretion, it is used (generally as its sodium or magnesium
alt) for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome.
Esomeprazole Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Esomeprazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 424)Lieferanten
119141-88-7()Verwandte Suche:
- EsoMeprazole EC Pellets 22%
- 1H-BenziMidazole,6-Methoxy-2-[(S)-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfinyl]-
- EsoMeprazole EC Pellets 8.5%
- 6-Methoxy-2-{(S)-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]sulfinyl}-1H-benziMidazole
- Esomeprazole(Na、Mg)
- (5-methoxy-1H-benzimidazol-2-yl)[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfoniumolate
- (S)-Esomeprazole
- Esomeprazole(Mg)
- 5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2- pyridinyl)methyl)sulfinyl)-1H-benzimidazole
- 6-Methoxy-2-[(R)-(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]-1H-benzoimidazole
- Esomeprazole
- (RelCpd F)
- (S)-5-Methoxy-2-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methylsulfinyl)-1H-benzo[d]iMidazole
- 119141-58-6
- esomeprazole:5-methoxy-2-((s)-((4-methoxy-3,5-dimethyl-2- pyridinyl)methyl)sulfinyl)-1h-benzIMIDAZOLE
- -6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)
- Aisi'aomeilazuona Esomeprazole Sodium
- Omeprazole S-Isomer
- Esomeprazol EP Impurity F
- Esomeprzole
- Esomeprazole USP/EP/BP
- Esomeprazole Monomer
- (-)-Omeprazole
- Esomeprazole D3 K salt
- EsomeprazoleQ: What is
Esomeprazole Q: What is the CAS Number of
Esomeprazole
- 5-Methoxy-2-(4-Methoxy-3,5-diMethyl-pyridin-2-ylMethanesulfinyl)-1H-benzoiMidazole
- 5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole
- (R)-5-Methoxy-2-(((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)sulfinyl)-1H-benzo[d]iMidazole
- (S)-6-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole
- ESOMEPRAZOLE 8.5%, 15.0%, 17%, 22%, 22.5%, 27.10% EC PELLETS
- (S)-5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole (Esomeprazole Impurity)
- EsoMaprozole
- Esomeprazol
- 119141-88-7
- 119141-58-6
- 217097-09-7
- 161798-78-7
- API
- 119141-88-7
