THYROIDHORMONE Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
The synthesis of thyroid hormone occurs within the follicles of the thyroid gland. The steps are as follows: (1) Inorganic iodide is transported into the gland; (2) Intrathyroidal iodide is oxidized to iodine under the influence of H2O2 and peroxidase (TPO); (3) Iodine is bound in thyroglobulin to tyrosine, forming monoiodotyrosine and diiodotyrosine; (4) The iodotyrosines are enzymatically coupled to form thyroxine (T4) and triiodothyronine (T3); (5) The iodothyronines, T4 and T3, are stored in thyroglobulin until released into the circulation; and (6) The unused iodotyrosines are deiodinated and the iodide is recycled. The heterodimer DUOX2/DUOXA2 complex supplies hydrogen peroxide for all steps of thyroid hormone synthesis catalyzed by TPO.
THYROIDHORMONE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
