甲狀腺ホルモン 化學特性,用途語,生産方法
解説
甲狀腺で生合成され，內分泌されるホルモンの総稱．ヨウ素原子が置換したベンゼン環(huán)をもつ分子構造が特徴で，チロキシン(T
4)と3,3',5-トリヨードチロニン(T
3)の2種類がある．若い動物の成長?成熟の促進や，成熟動物の基礎代謝(酸素消費，放熱，水分代謝)の維持などに働く．
合成
The synthesis of thyroid hormone occurs within the follicles of the thyroid gland. The steps are as follows: (1) Inorganic iodide is transported into the gland; (2) Intrathyroidal iodide is oxidized to iodine under the influence of H2O2 and peroxidase (TPO); (3) Iodine is bound in thyroglobulin to tyrosine, forming monoiodotyrosine and diiodotyrosine; (4) The iodotyrosines are enzymatically coupled to form thyroxine (T4) and triiodothyronine (T3); (5) The iodothyronines, T4 and T3, are stored in thyroglobulin until released into the circulation; and (6) The unused iodotyrosines are deiodinated and the iodide is recycled. The heterodimer DUOX2/DUOXA2 complex supplies hydrogen peroxide for all steps of thyroid hormone synthesis catalyzed by TPO.
甲狀腺ホルモン 上流と下流の製品情報
原材料
準備製品