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Celastrol

Celastrol Struktur
34157-83-0
CAS-Nr.
34157-83-0
Englisch Name:
Celastrol
Synonyma:
Tripterine;TRIPTERIN;Celastro;Celastrol (NSC 70931);NSC70931;Celatrol;CELASTROL;Celasterol;Celastrol(P);CELASTROL(SH)
CBNumber:
CB7146431
Summenformel:
C29H38O4
Molgewicht:
450.61
MOL-Datei:
34157-83-0.mol

Celastrol Eigenschaften

Schmelzpunkt:
219-230°C
Siedepunkt:
645.7±55.0 °C(Predicted)
Dichte
1.2
storage temp. 
-20°C
L?slichkeit
DMSO: >10mg/mL
pka
4.78±0.70(Predicted)
Aggregatzustand
solid
Farbe
red
maximale Wellenl?nge (λmax)
424nm(MeOH)(lit.)
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey
KQJSQWZMSAGSHN-JJWQIEBTSA-N
SMILES
[C@]12(C)CC[C@@]3(C)CC[C@@](C)(C(=O)O)C[C@@]3([H])[C@]1(C)CC[C@@]1(C)C3=CC(C(O)=C(C)C3=CC=C21)=O |&1:0,4,8,14,16,20,r|
LogP
7.080 (est)
CAS Datenbank
34157-83-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 25
S-S?tze: 45-24/25
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  2
RTECS-Nr. YJ7900000
HS Code  29189900
Speicherklasse 11 - Combustible Solids
Bildanzeige (GHS) Skull and Crossbones (GHS06)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Celastrol Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Orange Red Solid

Verwenden

Celastrol is an antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. It is also a leptin sensitizer with the potential to reduce weight in obesity.

Verwenden

An antioxidant natural product Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be

Definition

ChEBI: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. otently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).

Allgemeine Beschreibung

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biologische Aktivit?t

Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF- α -induced NF κ B activation. Also shown to inhibit topoisomerase II activity in vitro (IC 50 = 7.41 μ M).

Celastrol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Celastrol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 483)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-173 9270 1263
1057@dideu.com China 3998 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-86-13131129325 +8613131129325
sales1@chuanghaibio.com China 5229 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20122 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3692 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+86-15350851019; +8615350851019
admin@86-ss.com China 999 58
Guangzhou PI PI BIOTECH INC
+86-86-020-81716320 +8613602409664
Sales@pipitech.com China 973 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 33024 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58

34157-83-0()Verwandte Suche:


  • (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacid
  • Celastrol ,98%
  • (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
  • 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid
  • 3-Hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
  • Celastrol(Tripterine)
  • NSC70931
  • (2r,4as,6as,6ar,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
  • 3-HYDROXY-9BETA,13ALPHA-DIMETHYL-2-OXO-24,25,26-TRINOROLEANA-1(10),3,5,7-TETRAEN-29-OIC ACID
  • 3-HYDROXY-24-NOR-2-OXO-1(10),3,5,7-FRIEDELATETRAEN-29-OIC ACID
  • 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oicacid, 3-hydroxy-9,13-dimethyl-2-oxo-, (9β,13α,14β,20α)-
  • (9,13a,14,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid
  • 3-Hydroxy-2-oxo- 24-nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid
  • CELASTROL(SH)
  • CELASTROL
  • Celastrol (Tripterin)
  • CELASTROL(P)(PLEASE CALL)
  • (20R)-3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid
  • 2-Oxo-3-hydroxy-24-norfriedela-1(10),3,5,7-tetraene-29-oic acid
  • 2-Oxo-3-hydroxy-24-norfriedelane-1(10),3,5,7-tetraene-29-oic acid
  • Celasterol
  • Celastrol, 98%, Protease inbibitor
  • Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem
  • good price Celastrol 34157-83-0
  • Factory Provide Pure Natural 98% Celastrol Powder 34157-83-0
  • 10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
  • Celastrol >
  • Celatrol
  • (2S,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
  • Celastrol USP/EP/BP
  • Celastrol tripterine estratto
  • (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
  • 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid,3-hydroxy-9,13-dimethyl-2-oxo-, (9b,13a,14b,20a)-
  • Celastro
  • (2r,4as,6as,6ar,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylicacid
  • (9,13a,14,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-
  • 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oicacid,3-hydroxy-9,13-dimethyl-2-oxo-,(9β,13α,14β,20α)-
  • Celastrol -RM
  • Celastrol(P)
  • Celastrol from Celastrus scandens, Anti-inflammatory and antiproliferative agent
  • Tripterin, 10 mM in DMSO
  • Celastrol, Celastrus scandens
  • Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem[219465]
  • Tripterin (Standard)
  • Celastrol (NSC 70931)
  • TRIPTERIN
  • Tripterine
  • 34157-83-0
  • C29H38O4
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • ProteasomeInhibitors
  • Natural Anti-cancer Medical Materials and It's Derivatives
  • Miscellaneous Natural Products
  • Inhibitors
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