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gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1)

Chlorphenamine maleate Struktur
113-92-8
CAS-Nr.
113-92-8
Bezeichnung:
gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1)
Englisch Name:
Chlorphenamine maleate
Synonyma:
Chlorpheniramine maleate;chlorphenamine;CHLORPHENIRAMINE BASE;CHLORTRIMETON;CHLOROPHENIRAMINE MALEATE;Puermin;piriton;teldrin;Histadur;antagonate
CBNumber:
CB9142008
Summenformel:
C20H23ClN2O4
Molgewicht:
390.86
MOL-Datei:
113-92-8.mol

gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Eigenschaften

Schmelzpunkt:
130-135 °C (lit.)
alpha 
-1~+1°(D/20℃)(c=5,DMF)
Dichte
1.1984 (rough estimate)
Brechungsindex
1.6800 (estimate)
Flammpunkt:
9℃
storage temp. 
2-8°C
L?slichkeit
Freely soluble in water, soluble in ethanol (96 per cent)
Aggregatzustand
Solid
Farbe
White to Almost white
Geruch (Odor)
odorless
PH
4.0~5.5 (10g/l, 25℃)
Wasserl?slichkeit
1-5 g/100 mL at 21 ºC
Merck 
14,2180
BCS Class
3/1
InChI
1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
DBAKFASWICGISY-BTJKTKAUSA-N
SMILES
CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
LogP
3.389 (est)
EPA chemische Informationen
Chlorpheniramine maleate (113-92-8)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T,F
R-S?tze: 25-39/23/24/25-23/24/25-11
S-S?tze: 36/37/39-45-36/37-16
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. US6504000
TSCA  TSCA listed
HazardClass  6.1(b)
PackingGroup  III
HS Code  29333990
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Toxizit?t LD50 orally in mice: 162 mg/kg (Smith)
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit

gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R25:Giftig beim Verschlucken.

S-S?tze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Beschreibung

Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

Chemische Eigenschaften

White Solid

Verwenden

(±)-Chlorpheniramine maleate salt has been used:
  • as H1 receptor antagonist to determine the receptor function
  • to block the effect of compound 48/80 on plasma IGF-I
  • as a standard for fast sensing and determination by sequential injector coupled with potentiometer

Allgemeine Beschreibung

Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.

Air & Water Reaktionen

Water soluble.

Reaktivit?t anzeigen

A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Brandgefahr

Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.

Sicherheitsprofil

Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 816)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Chuanghai Biotechnology Co., Ltd
+86-15350571055
Sibel@chuanghaibio.com China 8738 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81139210 17389186172
1077@dideu.com China 3796 58
Wuhan Fortuna Chemical Co., Ltd
+86-27-59207850
info@fortunachem.com China 6001 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
+86-029-86333380 +86-18829239519
sales06@tgybio.com China 898 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-86-13131129325
sales1@chuanghaibio.com China 5220 58
shandong perfect biotechnology co.ltd
+86-53169958659 +86-13153181156
sales@sdperfect.com China 294 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971
deasea125996@gmail.com China 2472 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20120 58
Shanghai Affida new material science and technology center
+86-15081010295
admin@oudaxin.com China 114 58
airuikechemical co., ltd.
+86-18353166132
sales02@airuikechemical.com China 983 58

113-92-8(gamma-(4-Chlorphenyl)-N,N-dimethyl-2-pyridin-propanamin-,(Z)-2-butendioat (1:1))Verwandte Suche:


  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethy-laminopropanebimaleate
  • 1-Parachlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
  • Chlorprophenpyridamine maleate
  • Cloropiril
  • Histaspan
  • Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, maleate (1:1) (8CI)
  • (+-)-Chloropheniramine
  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
  • 2-[p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine
  • 2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-
  • 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
  • 4-Chloropheniramine
  • 9: PN: US20030109453 SEQID: 8 claimed sequence
  • Allergican
  • Chlorophenylpyridamine
  • Chloroprophenpyridamine
  • Chlorprophenpyridamine
  • dl-1-(p-Chlorophenyl)-1-(2-pyridyl)-3-(dimethylamino)propane
  • Haynon
  • RS-Chlorpheniramine
  • γ-(4-Chlorophenyl)-γ-(2-pyridyl)propyldimethylamine
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin maleate
  • 1-(p-chlorophenyl)-1-(2-pyridyl)-3-n,n-dimethylpropylamine
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridin
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
  • 2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]pyridine
  • gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin
  • CHLOROPHENIRAMINE BASE
  • Chlorpheniramine (base and/or unspecified salts)
  • 1-(N,N-Dimethylamino)-3-(p-chlorophenyl)-3-(alpha-pyridyl)propane maleate
  • 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • Chlorphenamine hydrogen maleate
  • 1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropanmaleat
  • 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)
  • allerclor
  • allergin
  • alunex
  • carbinoxamidemaleate
  • chlormene
  • chloroprophenpyridaminemaleate
  • chlor-tripolon
  • c-meton
  • dl-2-(p-chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridinemaleate
  • gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioa
  • gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate
  • histadurdura-tabs
  • ibioton
  • lorphen
  • m.p.chlorcapst.d.
  • nci-c55265
  • neorestamin
  • piriex
  • polaronil
  • pyridamal-100
  • synistamin
  • LABOTEST-BB LT00134667
  • (+/-)-CHLORPHENIRAMINE MALEATE SALT
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