5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
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- CAS-Nr.
- 870483-87-7
- Englisch Name:
- 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
- Synonyma:
- GW2580;CS-621;SC-203877;GW2580, >=98%;GW2580,GW-2580;SC-203877/GW2580;GW2580 (SC203877);GW2580, 10 mM in DMSO;GW2580 (DMSO solution);GW 2580; GW-2580; GW 2580.
- CBNumber:
- CB72510269
- Summenformel:
- C20H22N4O3
- Molgewicht:
- 366.41
- MOL-Datei:
- 870483-87-7.mol
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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Eigenschaften
- Siedepunkt:
- 617.5±65.0 °C(Predicted)
- Dichte
- 1.252±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: soluble10mg/mL, clear (warmed)
- Aggregatzustand
- powder
- pka
- 7.11±0.10(Predicted)
- Farbe
- white to beige
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- 1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
- InChIKey
- MYQAUKPBNJWPIE-UHFFFAOYSA-N
- SMILES
- Nc1nc(c(cn1)Cc2cc(c(cc2)OCc3ccc(cc3)OC)OC)N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn,Xi |
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| R-S?tze: |
22-36/37/38 |
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| S-S?tze: |
26-36/37/39 |
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| WGK Germany |
3 |
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| HS Code |
2933.59.8000 |
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| Speicherklasse |
11 - Combustible Solids |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
GW2580 has been used to study its effect on paracrine signaling from stretched cardiomyocyte on cardiac fibroblast phenotype.
Biochem/physiol Actions
GW2580 is a cell-permeable, potent and selective ATP-competitive inhibitor of cFMS kinase, receptor for macrophage-colony stimulating factor, M-CSF or CSF-1, and a key regulator of macrophage and osteoclast activation and differentiation. FMS is a type III receptor tyrosine kinase that binds to the macrophage or monocyte colony-stimulating factor (M-CSF or CSF-1). Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states including the growth of metastasis of some types of cancer, in promoting osteoclast proliferation in bone osteolysis, and in several inflammatory disorders. GW2580 selectively inhibits cFMS-mediated cellular functions in vitro at 0.06 μM as well as CSF-1-dependent tumor growth in vivo. GW2580 was inactive against 26 other kinases.
5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 184)Lieferanten
870483-87-7()Verwandte Suche:
- 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
- SC-203877
- SC-203877/GW2580
- 2,4-Pyrimidinediamine, 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-
- 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-Pyrimidinediamine
- 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine
- GW2580, >=98%
- cFMS Receptor Tyrosine Kinase Inhibitor
- cFMS receptor TK inhibitor
- GW 2580; GW-2580; GW 2580.
- CS-621
- cFMS Receptor Tyrosine Kinase Inhibitor - CAS 870483-87-7 - Calbiochem
- GW2580,GW-2580
- 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine USP/EP/BP
- GW2580 (SC203877)
- GW2580 (DMSO solution)
- GW2580 (DMSO solution), cFMS RTK inhibitor
- GW 2580, cFMS RTK inhibitor
- GW2580, 10 mM in DMSO
- GW2580
- 870483-87-7
- Inhibitors
