ChemicalBook >?? ???? >??? ??>???>??? ??? ????>5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine
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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine ??
- ?? ?
- 617.5±65.0 °C(Predicted)
- ??
- 1.252±0.06 g/cm3(Predicted)
- ?? ??
- -20°C
- ???
- DMSO: ???10mg/mL, ??(??)
- ??? ??
- ??
- ?? ?? (pKa)
- 7.11±0.10(Predicted)
- ??
- ???? ????
- ???
- ?? 3?? ?? -20°? DMSO? ??
- InChI
- 1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24)
- InChIKey
- MYQAUKPBNJWPIE-UHFFFAOYSA-N
- SMILES
- Nc1nc(c(cn1)Cc2cc(c(cc2)OCc3ccc(cc3)OC)OC)N
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 22-36/37/38 | ||
| ????? | 26-36/37/39 | ||
| WGK ?? | 3 | ||
| HS ?? | 2933.59.8000 | ||
| ???? ??? | 11 - Combustible Solids |
5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine C??? ??, ??, ??
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GW2580 has been used to study its effect on paracrine signaling from stretched cardiomyocyte on cardiac fibroblast phenotype.Biochem/physiol Actions
GW2580 is a cell-permeable, potent and selective ATP-competitive inhibitor of cFMS kinase, receptor for macrophage-colony stimulating factor, M-CSF or CSF-1, and a key regulator of macrophage and osteoclast activation and differentiation. FMS is a type III receptor tyrosine kinase that binds to the macrophage or monocyte colony-stimulating factor (M-CSF or CSF-1). Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states including the growth of metastasis of some types of cancer, in promoting osteoclast proliferation in bone osteolysis, and in several inflammatory disorders. GW2580 selectively inhibits cFMS-mediated cellular functions in vitro at 0.06 μM as well as CSF-1-dependent tumor growth in vivo. GW2580 was inactive against 26 other kinases.5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine ?? ?? ? ???
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5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine ?? ??
???( 184)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
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| Alchem Pharmtech,Inc. | 8485655694 |
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| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
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| Dideu Industries Group Limited | +86-86-15536356810 +8617392712697 |
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| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 |
info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; |
sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
| GLR Innovations | -- |
info@glrgroup.in | India | 4535 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 |
trendseenbio@gmail.com | China | 11680 | 58 |
5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine ?? ??:
GW284543
GW788388
GW9662
GW441756
GW5074
BUTEIN
Cabozantinib
Saracatinib
Pictilisib
Sunitinib Malate
Afatinib
mycotrienin II
SU 4312
LDN 193189 hydrochloride
HARMINE HYDROCHLORIDE
GW 284543 hydrochloride - UNC 10225170 hydrochloride
GW9508
2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-