Baricitinib phosphate salt
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- CAS-Nr.
- 1187595-84-1
- Englisch Name:
- Baricitinib phosphate salt
- Synonyma:
- INCB-28050;INCB424-ANALOGUE;LY-3009104 phosphate;INCB028050 phosphate);INCB-28050; LY3009104;Baricitinib (phosphate);Baricitinib phosphate salt;INCB424-Analogue (INCB-28050);Baricitinib phosphate, 10 mM in DMSO;Baricitinib phosphate (LY3009104 phosphate
- CBNumber:
- CB72621127
- Summenformel:
- C16H20N7O6PS
- Molgewicht:
- 469.412061
- MOL-Datei:
- 1187595-84-1.mol
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Baricitinib phosphate salt Eigenschaften
- storage temp.
- Store at -20°C
- L?slichkeit
- insoluble in EtOH; insoluble in H2O; ≥172.6 mg/mL in DMSO
- Aggregatzustand
- White powder.
- Farbe
- White to yellow
- InChIKey
- FBPOWTFFUBBKBB-UHFFFAOYSA-N
- SMILES
- C(#N)CC1(N2C=C(C3=NC=NC4NC=CC=43)C=N2)CN(S(CC)(=O)=O)C1.P(O)(O)(O)=O
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Baricitinib phosphate salt Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Baricitinib phosphate salt is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.
in vitro
In cell-based assays, Baricitinib phosphate proves to be a potent inhibitor of JAK signaling and function. In PBMCs, Baricitinib inhibits IL-6-stimulated phosphorylation of the canonical substrate STAT3 (pSTAT3) and subsequent production of the chemokine MCP-1 with IC50 values of 44 nM and 40 nM, respectively. In isolated naive T-cells, INCB028050 also inhibits pSTAT3 stimulated by IL-23 (IC50=20 nM). Importantly, this inhibition prevented the production of two pathogenic cytokines (IL-17 and IL-22) produced by Th17 cells-a subtype of helper T cells with demonstrable inflammatory and pathogenic properties-with an IC50 value of 50 nM. In stark contrast, the structurally similar but ineffective JAK1/2 inhibitors INCB027753 and INCB029843 has no significant effect in any of these assays systems when tested at concentrations up to 10 μM.
Baricitinib phosphate salt Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Baricitinib phosphate salt Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 148)Lieferanten
1187595-84-1()Verwandte Suche:
- 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile phosphate
- Baricitinib phosphate salt
- INCB-28050
- INCB-28050; LY3009104
- Baricitinib (phosphate)
- [1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl]acetonitrile phosphate
- INCB424-Analogue (INCB-28050)
- INCB-028050;LY-3009104;INCB 028050;LY 3009104;INCB028050;LY3009104
- Baricitinib phosphate (LY3009104 phosphate
- BARICITINIB PHOSPHATE (LY3009104 PHOSPHATE; INCB028050 PHOSPHATE)
- INCB028050 phosphate)
- LY-3009104 phosphate
- Baricitinib phosphate (LY-3009104, INCB-028050, Olumiant)
- Baricitinib phosphate, 10 mM in DMSO
- INCB424-ANALOGUE
- 2-(3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile, phosphate salt
- 1187595-84-1
- C16H17N7O2SH3PO4
- C16H20N7O6PS
- C16H17N7O2SH3O4P
- Inhibitors
