Baricitinib
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- CAS-Nr.
- 1187594-09-7
- Englisch Name:
- Baricitinib
- Synonyma:
- Olumiant;Baricitinib-API;1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile;Barrickini;Baricitinib (LY3009104, INCB028050);CS-574;Baricinix;Baritinib;LY 3009104;Barectinib
- CBNumber:
- CB82620596
- Summenformel:
- C16H17N7O2S
- Molgewicht:
- 371.42
- MOL-Datei:
- 1187594-09-7.mol
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Baricitinib Eigenschaften
- Schmelzpunkt:
- 212-215°C
- Dichte
- 1.56
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 30 mg/ml) or in DMF (up to 50 mg/ml).
- pka
- 11.66±0.50(Predicted)
- Aggregatzustand
- solid
- Farbe
- White or off-white
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
- InChI
- InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
- InChIKey
- XUZMWHLSFXCVMG-UHFFFAOYSA-N
- SMILES
- N1(S(CC)(=O)=O)CC(N2C=C(C3N=CN=C4NC=CC4=3)C=N2)(CC#N)C1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
WGK 3 |
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| HS Code |
29350090 |
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| Speicherklasse |
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications |
Repr. 1B
STOT RE 1
STOT SE 3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Baricitinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Charakteristisch
Primary targets: JAK1/2
Class: non-receptor tyrosine kinase
Treatment: rheumatoid arthritis
Oral bioavailability = 79%
Elimination half-life = 12.5 h
Protein binding = 50%
Verwenden
Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.
Baricitinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Baricitinib Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 573)Lieferanten
- Baricitinib
- INCB 028050
- LY 3009104
- BARICITINIB;INCB28050;LY3009104
- Baricitinib (LY3009104)
- 2-(3-(4-(3H-Pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
- Baricitinib/INCB 028050/LY3009104
- 3-Azetidineacetonitrile, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-
- 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile Baricitinib (LY3009104, INCB028050)
- 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile
- Baricitinib(INCB 028050
- Baricitinib, >=98%
- aricitinib (LY3009104, INCB028050)
- INCB028050; INCB-028050; INCB 028050; LY3009104; LY-3009104; LY 3009104; BARICITINIB; OLUMIANT
- Baricitinib Chemical Structure
- CS-574
- pharmaceutical grade and factory supply with Baricitinib CAS 1187594-09-7
- Barrettinib
- Baricitinib-007
- INCB028050 LY 3009104
- Baricitinib USP/EP/BP
- Baloxavir axetil
- 2-[1-(ethanesulfonyl)-3-(4-{7H-pyrrolo[2,3-d]pyrimi
din-4-yl}-1H-pyrazol-1-yl)azetidin-3-yl]acetonitrile
- Baricitinib (LY3009104, INCB028050)
- Barrickini
- Baracitinib
- 1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile
- Inhibitor,LY-3009104,JAK,Janus kinase,Baricitinib,INCB 028050,LY 3009104,INCB-028050,inhibit
- 2-1-Ethylsulfonyl-3-4-(7H-pyrrolo2,3-dpyrimidin-4-yl)-1H-pyrazol-1-ylazetidin-3-ylacetonitrile
- Baricinix
- Baritinib
- Baricitinib（For R & D only）
- Barectinib
- Baricitinib, 10 mM in DMSO
- Baricitinib - Bio-X ?
- 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
- Baricitinib-API
- Olumiant
- 1187594-09-7
- 1187594-07-9
- JAK
- STAT
- API
- Inhibitors
- Inhibitor
- JAK/STAT
- 1187594-09-7
- 1
