CD152:FC (HUMAN)-MULG FUSION PROTEIN Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Allgemeine Beschreibung

The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain in which mutations to the complement (C1q) and FcγR I binding sites of the Fcγ2a fragment render the Fc fusion protein incapable of direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

Biochem/physiol Actions

CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.

CD152:FC (HUMAN)-MULG FUSION PROTEIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

CD152:FC (HUMAN)-MULG FUSION PROTEIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Merck KGaA	--	ordercn@merckgroup.com	China	6394	58

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• CD152/FC CHIMERA, CYTOLYTIC
• CD152/FC CHIMERA, NON-CYTOLYTIC
• CD152-FC FUSION PROTEIN, HUMAN
• CD152:FC (HUMAN)-MULG FUSION PROTEIN
• CD152/Fc Chimera, Cytolytic from mouse
• CD152/Fc Chimera, Non-cytolytic from mouse
• CTLA4/FC CHIMERA, CYTOLYTIC
• CTLA4/FC CHIMERA, NON-CYTOLYTIC
• CTLA-4:FC (HUMAN)-MULG FUSION PROTEIN
• CTLA-4 MULG FUSION PROTEIN, HUMAN