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Carbidopa Monohydrate

Carbidopa Monohydrate Struktur
38821-49-7
CAS-Nr.
38821-49-7
Englisch Name:
Carbidopa Monohydrate
Synonyma:
CARBIDOPA;CARBIDOPA HYDRATE;(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid;lodosyn;Kabidopa;Carbidopa RS;CARBIDOPA,USP;Carbidopa CRS;Carbidopa (400 mg);Carbidopa(CEP/FDA)
CBNumber:
CB7445183
Summenformel:
C10H16N2O5
Molgewicht:
244.25
MOL-Datei:
38821-49-7.mol

Carbidopa Monohydrate Eigenschaften

storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.
Aggregatzustand
Solid
Farbe
White to Off-White
Major Application
pharmaceutical
pharmaceutical small molecule
InChI
InChI=1/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/s3
InChIKey
QTAOMKOIBXZKND-MEQOOBBNNA-N
SMILES
[C@@](C)(NN)(C(=O)O)CC1C=CC(O)=C(O)C=1.O |&1:0,r|
CAS Datenbank
38821-49-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. MW5300000
HazardClass  IRRITANT
HS Code  2928002500
Speicherklasse 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Toxizit?t mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
Bildanzeige (GHS) Exclamation Mark (GHS07)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Carbidopa Monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

white or yellowish-white powder. almost odorless. combined with levodopa for Parkinson's disease and Parkinson's syndrome.

Verwenden

Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth.

Definition

ChEBI: Carbidopa is the hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor, an antiparkinson drug, a dopaminergic agent and an antidyskinesia agent. It is a member of hydrazines, a hydrate, a monocarboxylic acid and a member of catechols. It contains a carbidopa (anhydrous).

Allgemeine Beschreibung

Carbidopa, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, is a whitecrystalline powder, slightly soluble in water (pKa=7.8).Carbidopa is absorbed slower than levodopa and is 36%plasma protein bound.Carbidopa is metabolized to twomain metabolites (α-methyl-3-methoxy-4-hydroxyphenylpropionicacid and α-methyl-3,4-dihydroxyphenylpropionicacid). These two metabolites are primarily eliminated in theurine unchanged or as glucuronide conjugates. Unchangedcarbidopa accounts for 30% of the total urinary excretion.No drug interactions have been described.

Carbidopa Monohydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Carbidopa Monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 359)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
APOLLO HEALTHCARE RESOURCES
+6596580999
sales@apollo-healthcare.com.sg Singapore 399 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 310 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
+86-13017695106 +86-13676922317
jiuyitime@fdachem.com China 16512 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21587 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3619 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29815 58
Casorganics US Corp
+17326109938
sales@casorganics.com CHINA 174 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 742 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19936 58

38821-49-7()Verwandte Suche:


  • Carbidopa SynonyMs (+)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropionic acid Monohydrate
  • (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate
  • Carbidopa for system suitability
  • CARBIDOPA MONOHYDRATE
  • (S)-(-)-CARBIDOPA MONOHYDRATE
  • CARBIDOPA 1-HYDRATE
  • CARBIDOPA 1-HYDRATE, PHARMA
  • CARBIDOPA,USP
  • CARBIDOPA(GMP CERTIFICATE)
  • (+)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropionic acid monohydrate
  • Carbidopa (400 mg)
  • (-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamicacidmonohydrat
  • (-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methyl-hydrocinnamicacimonohydr
  • alpha-hydrazino-3,4-dihydroxy-alpha-methyl-benzenepropanoicacimonohydra
  • lodosyn
  • Carbidopa(CEP/FDA)
  • 3-(4-(3-Butyl-3-methyltriaz-1-en-1-yl)phenyl)propanehydrazide
  • Carbidopa CRS
  • Carbidopa Monohydrate>
  • Carbidopa for system suitability CRS
  • Carbidopa RS
  • (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate
  • Carbidopa Monohydrate USP/EP/BP
  • Carbidopa for system suitability (Y0001713)
  • Carbidopa (1095506)
  • Carbidopa Capsules
  • Carbidopa monohydrate, 10 mM in DMSO
  • Kabidopa
  • (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid
  • CARBIDOPA
  • CARBIDOPA HYDRATE
  • 38821-49-7
  • 38812-49-7
  • 156-2-26
  • C10H14N2O4H2O
  • Inhibitors
  • Pharmaceutical intermediates
  • Other APIs
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