38821-49-7
中文名稱
卡比多巴
英文名稱
Carbidopa Monohydrate
CAS
38821-49-7
分子式
C10H16N2O5
MDL 編號
MFCD00889211
分子量
244.25
MOL 文件
38821-49-7.mol
更新日期
2026/07/15 12:17:56
38821-49-7 結構式
基本信息
中文別名
卡比多巴單水合物卡比多巴
(S)-alpha-甲基-alpha-肼基-3,4-二羥基苯丙酸一水合物
卡比多巴
英文別名
CARBIDOPACARBIDOPA HYDRATE
CARBIDOPA MONOHYDRATE
(S)-(-)-CARBIDOPA MONOHYDRATE
(-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamicacidmonohydrat
(-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methyl-hydrocinnamicacimonohydr
alpha-hydrazino-3,4-dihydroxy-alpha-methyl-benzenepropanoicacimonohydra
lodosyn
CARBIDOPA 1-HYDRATE
CARBIDOPA 1-HYDRATE, PHARMA
CARBIDOPA,USP
CARBIDOPA(GMP CERTIFICATE)
(+)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropionic acid monohydrate
所屬類別
原料藥：抗震顫麻痹藥物理化學性質(zhì)
儲存條件Keep in dark place,Inert atmosphere,Room temperature
溶解度Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.
形態(tài)neat
顏色白色至灰白色
主要應用pharmaceutical
pharmaceutical small molecule
pharmaceutical small molecule
InChIInChI=1/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/s3
InChIKeyQTAOMKOIBXZKND-MEQOOBBNNA-N
SMILES[C@@](C)(NN)(C(=O)O)CC1C=CC(O)=C(O)C=1.O |&1:0,r|
CAS 數(shù)據(jù)庫38821-49-7(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞警告
危險性描述H302-H319
WGK Germany3
RTECS號MW5300000
危險等級IRRITANT
海關編碼2928002500
存儲類別11 - Combustible Solids
危險性類別Acute Tox. 4 Oral
Eye Irrit. 2
Eye Irrit. 2
毒性mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
38821-49-7(安全特性,毒性,儲運)
儲運特性
庫房低溫通風干燥毒性分級
中毒急性毒性
口服-大鼠 LD50: 4810 毫克/公斤; 口服-小鼠 LD50: 1750 毫克/公斤可燃性危險特性
熱分解排出有毒氮氧化物煙霧類別
有毒物質(zhì)滅火劑
水, 二氧化碳, 泡沫, 干粉常見問題列表
用途
卡比多巴為類白色絨毛狀結晶；幾乎無臭。與左旋多巴聯(lián)合應用，用于帕金森病和帕金森綜合征。生物活性
Carbidopa ((S)-(-)-Carbidopa) monohydrate 是一種外周型脫羧酶 (decarboxylase) 抑制劑，可用于帕金森病的研究。Carbidopa monohydrate 是一種選擇性芳香烴受體 (AhR) 調(diào)節(jié)劑。Carbidopa monohydrate 抑制胰腺癌細胞和腫瘤生長。體外研究
Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191.
Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC
50
=29 μM).
體內(nèi)研究
Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts.